Bullous pemphigoid (BP) is an autoimmune blistering disease, characterized by subepidermal blisters and mediated IgG autoantibodies against BP180 (type XVII collagen) BP230 structural proteins of the dermal-epidermal junction. Efgartigimod, engineered Fc fragment, inhibits FcRn activity, thereby decreasing serum autoantibodies. This pre-registration report describes a Phase 2/3 randomized, doub...

Hyaluronan (or hyaluronic acid; HA), a component of the extracellular matrix (ECM), is composed of repeating polymeric disaccharides of D-glucuronic acid and N-acetyl-D-glucosamine linked by a glucuronide bond. Hyaluronan is abundant in a variety of human tissues, including skin, umbilical cord, synovial fluid, cartilage, and skeletal tissues, and is turned over through the catabolic activity o...