Pendard syndrome is a genetic disorder that is usually associated with hearing loss in children and thyroid status called goiter, and sometimes affects the balance of the person. Researchers estimate that 7 to 8 percent of the total congenital hearing loss is Pandard's syndrome. A sign that a person may have mutated the SLC26A4 gene is a family history of hearing loss in the early days. Another...

Stiff person syndrome (SPS) is a rare autoimmune disease characterised by axial stiffness and episodic painful spasms. It associated with additional diseases cerebellar ataxia. Most patients SPS have high levels of glutamic acid decarboxylase (GAD) antibodies. The aetiology remains unclear but autoimmunity thought to play major part. We previously demonstrated overlap between anti-GAD ataxia gl...

Stiff-person syndrome (SPS) is a rare disorder, characterized by progressive fluctuating muscular rigidity and spasms. Glutamic acid decarboxylase (GAD) antibody is primarily involved in the pathogenesis of SPS and SPS is strongly associated with other autoimmune disease. Here we report three cases of patients with classical SPS finally confirmed by high serum level of GAD antibodies. All of ou...