The human ether-a-go-go-related gene (HERG) cardiac K(+) channels are one of the representative pharmacological targets for development of drugs against cardiovascular diseases such as arrhythmia. Panax ginseng has been known to exhibit cardioprotective effects. In a previous report we demonstrated that ginsenoside Rg3 regulates HERG K(+) channels by decelerating deactivation. However, little i...

Papovavirus K (K virus) is a murine papovavirus that produces a fatal interstitial pneumonia in newborn mice and a clinically inapparent infection in older animals. The present study was conducted to determine whether the virus produces latent infection in animals surviving acute infection and whether the infection can be reactivated by immunosuppression. Mice were inoculated by the oral route ...

Expression of the structurally and functionally distinct min K channel in Xenopus oocytes results in voltage-dependent potassium currents that activate with a characteristic slow time course. Application of a membrane-impermeable chemical cross-linking agent to oocytes expressing min K decreased the time-dependent current, increased its rate of activation, and induced persistently activated inw...

Purpose of this study was to compare different Machine Learning classifiers (C4.5, Support Vector Machine, Naive Bayes, K-NN) in the early prediction of outcome of the subjects in vegetative state due to traumatic brain injury. Accuracy proved acceptable for all compared methods (AUC > 0.8), but sensitivity and specificity varied considerably and only some classifiers (in particular, Support Ve...

We study the persistent homology of an Erdős–Rényi random clique complex filtration on n vertices. Here, each edge e appears independently at a uniform time $$p_e \in [0,1]$$ , and persistence cycle $$\sigma $$ is defined as $$p_2(\sigma ) / p_1(\sigma )$$ where $$p_1(\sigma are birth death times . show that if $$k \ge 1$$ fixed, then with high probability maximal k-cycle order $$n^{1/k(k+1)}$$

Persistent phosphors have the ability to emit light long after the excitation has ended, typically by using thermal energy to liberate previously trapped charges. Alternatively, also photons can be used for the detrapping, leading to optically stimulated luminescence (OSL). This particular field of phosphor research has seen a strong expansion over the past two decades, with a steady growth of ...

Sur1 knockout mouse beta-cells lack K(ATP) channels and show spontaneous Ca(2+) action potentials equivalent to those seen in patients with persistent hyperinsulinemic hypoglycemia of infancy, but the mice are normoglycemic unless stressed. Sur1(-/-) islets lack first phase insulin secretion and exhibit an attenuated glucose-stimulated second phase secretion. Loss of the first phase leads to mi...

persistent mullerian duct syndrome in a 71-year-old man, case report h. salehi md , m.r. vatani baf md received:27/06/06 sent for revision: 11/10/06 received revised manuscript: 07/02/07 accepted: 12/02/07 background and objective: normal sexual differentiation occurs in the 6th embryonic week and in a normal embryonic life. both wolffian and mullerian ducts are present until the onset of sexua...