BACKGROUND A case definition of Gulf War illness with 3 primary variants, previously developed by factor analysis of symptoms in a US Navy construction battalion and validated in clinic veterans, identified ill veterans with objective abnormalities of brain function. This study tests prestated hypotheses of its external validity. METHODS A stratified probability sample (n = 8,020), selected f...

Since the Persian Gulf War ended in 1991, veterans have reported diverse, unexplained symptoms. Some have wondered if their development of systemic lupus erythematosus, amyotrophic lateral sclerosis, or fibromyalgia might be related to Gulf War service. The authors used Cox proportional hazard modeling to determine whether regular, active-duty service personnel deployed to the Persian Gulf War ...

life in Gulf War era military personnel. Am J Epidemiol 2002;155: 899–907. 52 The International Classification of Diseases, 9th Revision, Clinical Modification. 5th edn. Salt Lake City: Medicode Publication, 1998. 53 SAS Institute Inc. SAS/STAT Software Version 9.0. Cary, NC: SAS Institute Inc.; 2002. 54 Gray GC, Coate BD, Anderson CM et al. The post-war hospitalization experience of U.S. veter...

BACKGROUND Military intelligence data published in a companion paper explain how chemical fallout from US and Coalition bombing of Iraqi chemical weapons facilities early in the air campaign transited long distance, triggering nerve agent alarms and exposing US troops. We report the findings of a population-based survey designed to test competing hypotheses on the impact on chronic Gulf War ill...

Troops in the Persian Gulf War have registered complaints consistent with CNS dysfunction that emerged after returning from the Gulf. A common experience among Persian Gulf War veterans was exposure to pyridostigmine bromide (PB) for prophylaxis against nerve gas exposure. To determine whether PB causes emergent CNS dysfunction, Wistar-Kyoto (WKY) and Sprague-Dawley (SD) rats were given PB for ...

Many Persian Gulf War veterans took pyridostigmine bromide (PB) during the Persian Gulf War. Previous research suggests that PB intake and insecticide exposure may reduce muscular strength. During 1994 and 1995, we examined the relationships between self-reported PB intake, self-reported exposures, and handgrip strength among 527 Gulf War veterans (GWVs) and 969 nondeployed veterans of that era...

Since the Persian Gulf War ended in 1991, many veterans have sought medical evaluation in the Department of Veterans Affairs Persian Gulf Veterans' Health Registry (VA registry) or the Department of Defense's Comprehensive Clinical Evaluation Program (DoD registry). Using combined data collected from 1993 to 1997 from the VA and DoD registries, the authors compared the characteristics of regist...

A total of 675,626 active duty Army soldiers who were known to be at risk for deployment to the Persian Gulf were followed from 1980 through the Persian Gulf War. Hospitalization histories for the entire cohort and Health Risk Appraisal surveys for a subset of 374 soldiers were used to evaluate prewar distress, health, and behaviors. Deployers were less likely to have had any prewar hospitaliza...

Numerous studies have investigated the health problems reported by veterans of the Persian Gulf War, but important questions remain. Epidemiologic studies have consistently indicated that Gulf War veterans report unexplained symptoms at significantly higher rates than veteran comparison groups but that they have not experienced excess rates of disease-related mortality. Addressing unanswered qu...

This chapter reviews available data concerning the degree to which deployment to the Persian Gulf theater was experienced as a stressful event by military personnel. After a brief overview of potential stresses faced by deployed personnel both during and after deployment, the chapter describes groups postulated to be at particularly high risk of negative reactions to stress exposure. Finally, t...