The aim of this experiment is to measure in vivo generation of melanin-derived radicals non-invasively, as a quantifiable index of radio-biological effect. Melanin-derived radicals in a living intact mouse tail tip were non-invasively measured in very simple way using an X-band electron paramagnetic resonance spectrometer. Colored mouse strains, C57BL/6NCr, BDF1, and C3H/He, have clear EPR sign...

AIM To study the effects of somatostatin (SST) and its antagonist cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr [Bzl]) (SSA) on morphine-induced analgesia. METHODS The pain assays were the hot plate and the tail flick test. RESULTS SST or SSA per se administered intracerebrally at the doses of 0.1 and 1 mg/mouse did not change the pain threshold of mice both in the hot plate and in the tail fli...

Givotia rottleriformis has been used in the indigenous systems of medicine for the treatment of inflammatory diseases like rheumatism and psoriasis. In order to evaluate this information, antipsoriatic activity of three flavonoids isolated from the ethanol extract of the bark of Givotia rottleriformis were investigated using in-vitro and in-vivo model, namely Rutin (I), Luteolin-7-O-β-D-Glucuro...

In a recent experiment Paoletti [Phys. Rev. Lett. 101, 154501 (2008)]10.1103/PhysRevLett.101.154501 monitored the motion of tracer particles in turbulent superfluid helium and inferred that the velocity components do not obey the Gaussian statistics observed in ordinary turbulence. Motivated by their experiment, we create a small 3D turbulent state in an atomic Bose-Einstein condensate, compute...

Crinkly-tail, cy, is a new recessive mutant with imperfect penetrance, in chromosome 4 of the mouse. The only abnormality is in the shape of the vertebrae for one, more rarely two, lengths of the region C9 to C14. This is expressed briefly in the 11-day-old embryo as a duplicated tail gut. None of the mechanisms operating in most of the 20 known tail mutants in the mouse operates in crinkly-tai...

Objective: The present study was carried out to investigate the neuropharmacological activities of ethyl acetate extract of Mimosa pudica (EAMP) leaves on anxiety, depression and memory in a mouse model. Materials and Methods: Anti-anxiety potential of EAMP was evaluated by elevated plus maze (EPM), light-dark box (LDB) and social interaction (SI) tests in mice.Anti-depressant potential of EAMP...

BACKGROUND Skin aging is associated with intrinsic processes that compromise the structure of the extracellular matrix while promoting loss of functional and regenerative capacity. These processes are accompanied by a large-scale shift in gene expression, but underlying mechanisms are not understood and conservation of these mechanisms between humans and mice is uncertain. RESULTS We used gen...