Background:Molecular biology and human medical genetics have introduced several novel biomarkers giving control over vital body functions, of these are transcriptional factors known as peroxisome proliferator activated- receptors “PPARs”. The aim this review is to shed light on available online information published research works about biomarkers. current will try display those findings mainly...

background:  we determined the blood lipid-lowering effects ofeicosapentaenoic acid (epa) on hypertriglyceridemic subjects with leu162/val in exon 5 and g/c in intron7 polymorphism of peroxisome proliferator-activated receptor alpha (pparα)genotypes that, to our knowledge, have not been previously studied. methods:  a total of170 hypertriglyceridemic subjects were enrolled and genotyped for ala...

the peroxisome proliferator-activated receptors (ppars) -α, -δ/β and -γ are the ligand-activated transcription factors involved in the regulation of fatty acid and lipoprotein metabolism, energy balance, cell proliferation and differentiation and atherosclerosis, etc. we investigated the associations of 10 single-nucleotide polymorphisms (snps) in ppars with apolipoprotein (apo) a-i/apob ratio ...

In this study we investigated if peroxisome proliferator-activated receptor β/δ activation protects from copper-induced acute liver damage. Mice treated with copper had significant body weight loss, serum alanine aminotransferase increase, modest changes in liver histology, increase of tumor necrosis factor α and macrophage inflammatory protein 2 mRNA and 8-hydroxy-2'-deoxyguanosine. Mice treat...

BACKGROUND Systemic therapeutics targeting the peroxisome proliferator-activated receptors have been found to be beneficial in the treatment of diabetic retinopathy. In this paper, we provide a rationale for the use of these therapeutics as intraocular agents. In addition, we introduce the peroxisome proliferator-activated receptors and describe their functions in response to the drugs. DISCU...

Peroxisome proliferators such as the fibrates act via the peroxisome proliferator activated receptor (PPAR)-alpha as hypolipidemic agents. Many peroxisome proliferators are also nongenotoxic hepatic carcinogens and hepatotoxicants in rodents. We performed transcription profiling using cDNA microarrays on livers of rats treated for 5 days with 3 doses of the peroxisome proliferator clofibrate. A...

Several decades ago, fibrates were approved for the treatment of dyslipidemia, whereas thiazolidinediones were screened in animal models to improve glucose homeostasis and were subsequently developed for the treatment of type 2 diabetes mellitus. Relatively recently, these drugs were found to act via peroxisome proliferator-activated receptors, nuclear receptors that control lipid metabolism an...

Submit Manuscript | http://medcraveonline.com J Nutr Health Food Eng 2015, 3(1): 00101 Abbreviations: UCP: Uncoupling Proteins; PGC1-α: Peroxisome Proliferator-Activated Receptor Gamma Co-Activator 1 Alpha; PPARα; Peroxisome Proliferator-Activated Receptor Alpha; BAIBA: β-Aminoisobutyric Acid; ROS: Reactive Oxygen Species; FFA: Free Fatty Acids; ETC: Electron Transport Chain; ATP: Adenosine Tri...