Several hypolipidemic drugs and certain industrial plasticizers induce proliferation of peroxisomes and enhance the activ ities of peroxisome-associated enzymes in the livers of rodents. Evidence now suggests that potent hepatic peroxisome proliferators as a class are carcinogenic, although they do not appear to be mutagenic in the Sa/mor>e//a-microsome assay system. We now report that long-ter...

Peroxisome inheritance at the right time and place E very yeast cell has numerous peroxi-somes—organelles that metabolize fatty acids— and roughly half are passed on to their daughter cells. Signaling from the bud to the mother cell ensures even peroxisome distribution by controlling the organelles' transport, say Fagarasanu et al. Peroxisomes travel into the bud along actin tracks using the my...

Background: Natural organic matter is the cause of many problems associated with water treatment such as the presence of disinfection by-products (DBPs) and membrane fouling during water filtration. In this study, the performance of the peroxi-electrocoagulation process (PEP) was investigated for the removal of humic acids (HAs) from aqueous solutions. Methods: PEP was carried out for the remov...

The mechanism of acceleration of lipid peroxide formation in the liver homogenate of vitamin E-deficient mice was investigated. The quantities of unsaturated fatty acid, NADPH, ascorbate and hemo protein, which have been so far thought to be the main factors of ac celeration of lipid peroxidation, could not be considered the major reason for acceleration in vitamin E-deficient liver homogenate....

Little attention has been given to the occurrence of exocellular hydrolytic enzymes associated with the roots of higher plants. Such enzymes, if present, could solubilize macromolecular constituents of organic soils, permitting uptake and utilization by the plant of the resultant low molecular weight organic compounds. The present work supports this concept by demonstrating that several exocell...

Peroxisomes were visualized in living plant cells using a yellow fluorescent protein tagged with a peroxisomal targeting signal consisting of the SKL motif. Simultaneous visualization of peroxisomes and microfilaments/microtubules was accomplished in onion (Allium cepa) epidermal cells transiently expressing the yellow fluorescent protein-peroxi construct, a green fluorescent protein-mTalin con...

Male F344 rats were fed a diet containing the peroxisome proliferators 2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropionic acid [ciprofibrate (0.025%)] or [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid [Wy-14643 (0.1%)] for up to 14 months to determine whether hepatic peroxisome prolifera tion caused by these agents results in the induction of membrane lipid peroxidation in the l...

Copperand zinc-containing Superoxide dismutase, man ganese-containing Superoxide dismutase, catalase, and glutathione peroxidase form the primary enzymic defense against toxic oxygen reduction metabolites. Such metabolites have been implicated in the damage brought about by ionizing radiation, as well as in the effects of several cytostatic com pounds. These enzymes were analyzed in 31 differen...