The most troublesome obstacle to the quantitative determination of the very minute quantities of iodine which are normally present in biological materials has been the destruction, without loss of iodine, of the relatively large amounts of organic matter present. The procedures which have been used to destroy the organic matter include fusion with alkali, combustion in a closed system, and dige...

A simple, rapid and highly sensitive spectrophotometric method is developed for the determination of risperidone in tablet formulation. The method is based on the oxidation of drug using potassium permanganate in alkaline medium and excess potassium permanganate oxidizes 1,10-phenanthroline Fe(II). The measurement of decrease in absorbance of 1,10-phenanthroline Fe (II) was done at 415 nm. The ...

Chemiluminescence from the vanadium and potassium permanganate reaction was studied under acidic conditions to develop a sensitive method for vanadium determination using the formaldehyde enhancement effect. The method was successfully applied to the determination of vanadium in seawater. Experimental parameters were optimized, including acid concentration, potassium permanganate and formaldehy...

Two new spectrophotometric methods using permanganate as the oxidimetric reagent for the determination of olanzapine (OLP) were developed and validated as per the current ICH guidelines. The methods involved the addition of known excess of permanganate to OLP in either acid or alkaline medium followed by the determination of unreacted permanganate at 550 nm (method A) or bluish-green color of m...

In studies of manganese deficiency in the rabbit,1 a method for the determination of this element in small samples of blood serum and other tissues was needed. The most promising of the organic reagents suitable for manganese appeared to be 4,4’-tetramethyldiaminodiphenylmethane, which has been used by Harry (1) in a calorimetric procedure and by Mellan (2) as a spot test reagent. Preliminary t...

A new chemiluminescence method using flow injection is described for the determination of four penicillins, namely: phenoxymethylpenicillin potassium, amoxicillin, ampicillin, and ampicillin sodium. The method is based on sensitizing effect of these drugs on the chemiluminescence reaction of potassium permanganate in sulfuric acid with glyoxal. The different experimental parameters affecting th...

Catalase activity may be measured quantitatively by the method of von Euler and Josephson (1) by allowing the enzyme solution to react with hydrogen peroxide for varying periods of time and measuring the excess peroxide remaining by titration with potassium permanganate. The similarity of this titration procedure to the assay of ascorbic acid by titration with 2:6-dichlorophenolindophenol sugge...