Background: Acute limb ischemia (ALI) is a sudden decrease in leg perfusion that threatens the viability of with symptom onset within 2 weeks. In peripheral artery disease (PAD) conditions, occlusion blood vessels can occur due to thrombosis or atherosclerotic plaque embolism, which called "acute on chronic ischemia". The development endovascular therapy has made this an important role restorin...

BACKGROUND Cardiovascular disease (CVD) is frequent in type 2 diabetes mellitus patients due to accelerated atherosclerosis. Plasma osteoprotegerin (OPG) has evolved as a biomarker for CVD. We examined the relationship between plasma OPG levels and different CVD manifestations in type 2 diabetes. METHODS Type 2 diabetes patients without known CVD referred consecutively to a diabetes clinic fo...

BACKGROUND Recent clinical use of vascular endothelial growth factor (VEGF) in the treatment of both myocardial and peripheral ischemia has suggested the possibility of tissue specific coregulation of VEGF and its receptors (eg, kinase domain region [KDR]). The present study was performed to detect the relationship between VEGF and KDR protein levels after acute myocardial and peripheral ischem...

BACKGROUND It is unknown if cardiac ischemia has any deleterious effect on the contractile properties of nonischemic, peripheral vascular beds. Thus, the objective of the present study was to determine whether acute myocardial ischemia results in peripheral vascular dysfunction. METHODS AND RESULTS This study characterized force maintenance and the sensitivity to acetylcholine (ACh)-mediated ...

Chronic lower limb ischemia is becoming increasingly common among patients worldwide. This a comorbid condition, which accompanied by chronic pain, trophic ulcers and gangrene, as well decrease in the quality of life. Despite nature ischemia, absence treatment high rate amputation mortality. It has been proven that with peripheral arterial disease extremities, risk cardiovascular events mortali...

Congenital X-linked retinoschisis (CXLRS) is characterized by symmetric bilateral macular involvement, usually beginning in the first decade of life and affecting males. In fundus examination, a wheel pattern developing due to schisis areas observed macula. Fundus examination optical coherence tomography (OCT) are essential for diagnosis early stages disease exhibit characteristic findings. Per...

Mitochondrial dysfunction has been identified as a possible early event in ischemia-reperfusion damage. The peripheral benzodiazepine receptor, a mitochondrial inner membrane protein, has already been proposed to play a role in mitochondrial regulation, although its exact function remains unclear. The aim of this work was to determine the role of peripheral benzodiazepine receptor in ischemia-r...

 Proximal humerus fractures are common, but associated injury of the axillary artery is uncommon. The majority of published blunt traumatic axillary artery injuries are associated with anterior glenohumeral dislocation; a few are associated with isolated proximal humerus fractures or fracture-dislocation. Experience within our institution demonstrates that axillary artery injury is often unreco...

Most centrally mediated sympathoexcitatory reflexes produce increases in arterial pressure, heart rate, and peripheral vascular resistance, including coronary vasoconstriction. Cerebral ischemia also causes large increases in arterial pressure and peripheral vasoconstriction but with modest or variable changes in heart rate. To examine the effect of cerebral ischemia on coronary vascular resist...

Introduction: Orexins are novel neuropeptides that are localized in neurons in the lateral hypothalamus. They are implicated in a wide variety of physiological functions. Orexin peptides and receptors are found in many peripheral organs such as kidneys. It has been demonstrated that exogenous orexin-A can induce protective effects against ischemia–reperfusion injury in many organs. The goal ...