peri-implantitis is a site-specifi c infectious disease that causes an infl ammatory process in soft tissues, and bone loss around an osseointegrated implant in function. the etiology of the implant infection is conditioned by the status of the tissue surrounding the implant, implant design, degree of roughness, external morphology, and excessive mechanical load. the microorganisms most commonl...

BACKGROUND AND PURPOSE Ceramic-on-ceramic articulation is an attractive alternative to metal-on-polyethylene (PE) bearings, but little is known about the in vivo effects induced by dissemination of alumina wear debris in the periprosthetic tissues. We hypothesized that wear debris is not the main factor responsible for loosening and failure of the implant but that mechanical problems caused by ...

Prosthetic wear debris-induced peri-implant osteolysis is a major cause of aseptic loosening after total joint replacement. In this condition, wear particles released from the implant components induce a granulomatous inflammatory reaction at the interface between implant and adjacent bone, leading to progressive bone resorption and loss of fixation. The present study was undertaken to characte...

objective: successful bonding of a dental implant to bone, which was referred to as osseointegration by branemark has been well documented. however, long-term prognosis of an implant depends on adequate maintenance and long-term care. an effective maintenance program is required to preserve the health of peri-implant tissues. several techniques have been suggested for this purpose but it is not...

Introduction: Osteoclast Associated Receptor (OSCAR) is a novel member of leucocyte receptor complex (LCR)-encoded family. Mouse OSCAR (mOSCAR) has been reported to be expressed by the preosteoclast and mature osteoclast (OC) (1). A putative ligand has been reported to be expressed primarily in osteoblast/stromal cells and OSCAR mRNA was detected in OC rich tissue such as skull and long bones (...

Particles generated from orthopedic implants through years of wear play an essential role in the aseptic loosening of a prosthesis. We have investigated the biocompatibility of these orthopedic particles on different osteoblast-like cells representative of different stages of osteoblast maturation. We found the particles induced a caspase-dependent apoptosis of osteoblasts, with less mature ost...

Background: Receptor activator of nuclear factor kappa B ligand (RANKL) is one of the key cytokines in the induction of osteoclastogenesis both in vitro and in vivo.Several reports indicated the presence of sRANKL in gingival crevicular fluid of patients with periodontal diseases. Objective: To determine the presence of RANKL in peri-implant crevicular fluid samples of implants with peri-implan...