Nonalcoholic fatty liver disease (NAFLD) is emerging as an important cause of liver disease in India. Epidemiological studies suggest prevalence of NAFLD in around 9% to 32% of general population in India with higher prevalence in those with overweight or obesity and those with diabetes or prediabetes. Clinicopathological studies show that NAFLD is an important cause of unexplained rise in hepa...

OBJECTIVE Dysregulation of tumour necrosis factor alpha (TNF alpha) production is thought to be important in rheumatoid arthritis. Since pentoxifylline and thalidomide inhibit endotoxin induced TNF production in vitro, these drugs were tested in an open study in rheumatoid arthritis patients to assess toxicity, the effect on TNF production, and the antiarthritic effects. METHODS 12 patients w...

Thromboangiitis obliterans (TAO) is a nonatherosclerotic, segmental inflammatory disease that most commonly affects the small and medium-sized arteries and veins in the upper and lower extremities. Cigarette smoking has been implicated as the main etiology of the disease. In eastern parts of the world TAO forms 40-60% of peripheral vascular diseases. Clinical features and angiographic finding a...

Hepatopulmonary syndrome is a rare complication of liver disease and portal hypertension. It has not been previously described in medical literature Nigeria. We report this case 64-year-old man who presented with 3 months’ history recurrent breathlessness, platypnoea leg swelling. He had diagnosed cirrhosis variceal band ligation 2018, managed for 2 episodes hepatic encephalopathy prior to refe...

BACKGROUND The prevalence of nonalcoholic fatty liver disease (NAFLD) has significantly increased over the last decades. Despite existence of several interventions, there remains unclear which interventions work the best. METHODS A systematic review and network meta-analysis of randomized trials comparing efficacy of all treatment options in NAFLD were performed to determine comparative effic...

Since 1970s, tamoxifen has widely been used in the adjuvant and metastatic settings and also in risk reduction of hormone receptor positive breast cancer. Long-term use of tamoxifen in the adjuvant setting of hormone receptor positive breast cancer, such as up to 5 or 10 years duration, is standard of care and associated with favorable survival outcomes, almost in all stages of disease. Symptom...

global cerebral ischemia (gci) and reperfusion induced apoptosis that lead to cell injury and death. the bax and bcl-2 are pro-apoptotic and anti-apoptotic genes, respectively. these genes belong to the b-cell lymphoma-2 (bcl-2) family.in this study; we assessed the effect of pentoxifylline drug on bax/bcl2 gene dosage expression changes following   ischemic reperfusion injury in kidney. in thi...