The quantity and duration of production of tumor necrosis factor (TNF) is tightly controlled due to its potential to cause serious harm. For example, TNF release in response to overwhelming bacterial infection has been implicated as the first step in potentially lethal septic shock. Prostaglandins and leukotrienes are thought to play opposing roles in regulating TNF production by monocytes and ...

BACKGROUND AND PURPOSE The majority of stroke patients are treated in local general hospitals. Despite this fact, little is known about stroke care in these institutions. We sought to investigate the status quo of acute stroke management in nonspecialized facilities with limited equipment and resources. METHODS Four general hospitals located in smaller cities of a rural area in Germany partic...

INTRODUCTION Clopidogrel is frequently associated with thrombotic thrombocytopenic purpura, however this drug is rarely related to severe isolated thrombocytopenia. Pentoxifylline has previously been associated with thrombocytopenia only once. To the best of our knowledge, this is the first report of severe isolated thrombocytopenia after therapy with both clopidogrel and pentoxyfilline. CASE...

Background & Aims: Liver ischemia-reperfusion (IR) is one of the common consequences of liver surgery, especially during liver transplantation which results in organ dysfunction. Acute hepatic injury causes systematic inflammatory responses which may finally lead to functional disturbances in remote organs such as heart, lungs and kidneys. In this study, the effects of a potent inhibitor of inf...

mdma generally known as ecstasy, have deleterious effects on the serotonergic neurotransmitter system. recent findings suggest that the liver and brain are major target organs of mdma-related toxicities. although most research is being dynamically performed on brain, however, the molecular mechanisms by which mdma elicits adverse effects in both organs are poorly undrestood.the present study wa...

"How diseases of the liver affect lung function?" is one of those puzzling questions that can turn obsessive for those who want to understand how two seemingly distinctive organs can interact and eventually lead to severe disorders [1, 2]. The most common respiratory consequence of liver disease is hypoxaemia, which is often mild to moderate [3]. Seldom severe hypoxaemia occurs when the arteria...

The main problem in schistosomal hepatic morbidity is fibrosis and extensive scarring induced by living eggs. In this study, we tried to study the effect of treatment using antihelminthic drug (PZQ) and/or antifibrotic drugs (PTX and silymarin) in combination with immunization. The parasitological parameters, the dynamics of serum-specific immunoglobulins and splenic cytokines associated with c...