The interactions of the anthelmintic agent avermectin B1a, the anticonvulsant pentobarbital, and the anxiolytic tracazolate with the gamma-aminobutyric acid (GABA) receptor . chloride ion channel complex in rat brain membrane were studied. The results indicated that they all potentiated ligand binding to the GABA and benzodiazepine receptors. The stimulatory effects of avermectin B1a and pentob...

We hypothesised that pentobarbital would improve upper airway mechanics based on an increase in latency to arousal and amplitude of the phasic genioglossus electromyogram (EMG), and a decrease in the active upper airway critical closing pressure (P(crit)). 12 healthy subjects received pentobarbital (100 mg) or placebo in a double-blind, crossover protocol. During wakefulness, we measured the ge...

introduction: anesthetic agents, blood pressure, arterial ph and blood gases have found to influence on the pathophysiology of experimental stroke. despite, there are very few comparative studies about effects of anesthetic agents in animal model of cerebral ischemia. therefore, in this study, we investigated the effects of chloral hydrate and pentobarbital anesthesia, as comparative study, on ...

Rosa damascena (Rosaceae) has been found to act on central nervous system including the brain. Several studies confirm that Rosa damascena inhibits the reactivity of the hypothalamus and pituitary systems in rat and can suppress the reactivity of central nervous system. In traditional medicine the hypnotic effect of rose is also suggested. In the present study hypnotic effect of ethanolic, aque...

Barbiturates were introduced into medical practice in 1934. They are widely used today as general anesthetics. Although in vitro studies revealed that the activity of a variety of ligand-gated channels is modulated by barbiturates, the target(s) mediating the anesthetic actions of barbiturates in vivo are unknown. Studying pentobarbital action in beta3(N265M) mice harboring beta3-containing GAB...

Synaptic plasma membranes (SPM) and myelin were prepared from mouse brain and their physical properties evaluated by fluorescence probes. 1,6,-Diphenyl-1,3,5-hexatriene (DPH) was used as a probe of the membrane core and endogenous tryptophan as a probe of membrane proteins. In vitro addition of pentobarbital or ethanol decreased the fluorescence polarization of DPH in SPM. These decreases were ...

The effects of inhalation anesthesia (2% isoflurane, sevoflurane, or enflurane) and intraperitoneal anesthesia with pentobarbital (65 mg/kg) were compared in rats using an electrocardiogram (ECG) and determination of blood oxygen saturation (SPO2) levels. Following inhalation anesthesia, heart rate (HR) and SPO2 were acceptable while pentobarbital anesthesia decreased HR and SPO2 significantly....

In the present study, four non-drug-abusing humans were trained to discriminate between a hypnotic dose of pentobarbital, 100 mg, and placebo. After acquiring the pentobarbital-placebo discrimination, a range of doses of zolpidem, triazolam, pentobarbital and caffeine were tested to determine whether they shared discriminative stimulus effects with the training dose of pentobarbital, Zolpidem, ...

Orally delivered pentobarbital was established as a reinforcer for 5 rhesus monkeys. The monkeys were food deprived throughout the study. LiQUid deliveries (0. 5 ml) were contingent upon 1 ip-contact responses on a drinking spout, and food pellet deliveries were contingent upon lever-press responses. Three-hr daily sessions were preceded and followed by 1-hr blackouts. In the initial phase wate...

traditionally, lactuca sativa (lettuce) has been recommended for its hypnotic property.the present study was planned to investigate sleep-prolonging effect of this plant. the hydroalcoholicextract (hae) of lettuce and its water fraction (wf), ethyl acetate fraction (eaf),and n-butanol fraction (nbf) were administrated (ip) to mice 30 min before the pentobarbitalinjection. moreover, both in-vivo...