Pediatric brain tumors are the most common solid tumors in children and are also a leading culprit of cancer-related fatalities in children. Pediatric brain tumors remain hard to treat. In this study, we demonstrated that medulloblastoma, pediatric glioblastoma, and atypical teratoid rhabdoid tumors express significant levels of acid ceramidase, where levels are highest in the radioresistant tu...

PURPOSE Adult cancer is frequently preceded by a period of prolonged chronic inflammation caused by infectious microbial agents or physical or chemical irritants. By contrast, an association between the classic pediatric neoplasias and inflammatory triggers is only rarely recognized. We hypothesized that the difference could be reflected in the inflammatory cell infiltrates of pediatric and adu...

background : labeling, gathering mutual information, clustering and classification of central nervous system tumors may assist in predicting not only distinct diagnoses based on tumor-specific features but also prognosis. this study evaluates the epidemi- ological features of central nervous system tumors in children who referred to mahak’s pediatric cancer treatment and research center in tehr...

Pediatric liver tumors account for approximately 1% of all liver tumors and up to 2% of all pediatric malignancies [1,2]. While the overall incidence of liver tumors is rare, the liver remains the third most common organ of origin for solid abdominal tumors in the pediatric population [3]. The majority of pediatric liver tumors, both benign and malignant, occur (almost) exclusively in children....

background: central nervous system (cns) tumors have accounted for approximately one fourth of all pediatric malignancies. cns tumors have been the most common solid malignancies among the children. in this study, we have evaluated survival and prognostic factors in children with non-brain stem astrocytoma. methods: children with non-brain stem astrocytoma, referring to radiation oncology cente...

how to cite this article: tabatabaei sm, seddighi a, seddighi as. posterior fossa tumor in children. iran. j. child. neurol 2012;6(2): 19-24.   objective primary brain tumors are the most common solid neoplasms of childhood, representing 20% of all pediatric tumors. the best current estimates place the incidence between 2.76 and 4.28/100,000 children per year. compared with brain tumors in adul...

Conventional anatomic brain MRI is often limited in evaluating pediatric brain tumors, the most common solid tumors and a leading cause of death in children. Advanced brain MRI techniques have great potential to improve diagnostic performance in children with brain tumors and overcome diagnostic pitfalls resulting from diverse tumor pathologies as well as nonspecific or overlapped imaging findi...

Introduction Pancreatic tumors are a rare entity, accounting for approximately 3% of cancers in the United States. Pediatric pancreatic tumors are an even rarer entity, with an incidence of 0.46 per million (under 30 years of age). The purpose of this article is to review the existing literature to give an overview of pediatric pancreatic tumors and to delineate current treatment strategies. Ma...