Autoantibodies directed against neuronal proteins have been identified in some patients with paraneoplastic cerebellar degeneration. To identify the molecular targets for these autoantibodies, we constructed a lambda gt11 cDNA expression library from human cerebellum and screened the library with IgG from a patient with paraneoplastic cerebellar degeneration. A single clone, pCDR2, produced a f...

Insufficient precipitation observations hinder the bias-correction of Global Climate Model (GCM) outputs in ungauged and remote areas. As a result, reliability future water resource projections is restricted for these Open-access quantitative estimation (QPE) products offer potential solution to this challenge. This study assesses effectiveness three widely used, long-term QPEs, including ERA5,...

Remote sensing technique is beneficial for rainfall data retrievals, however, enhancing the accuracy remains a challenge. In this study, novel framework based on broad learning system (BLS) was proposed to assimilate multi-source data. The dataset includes six satellite-based products (3B42V7, 3B42RT, IMERG, CBLD, GSMaP, and PCDR), gauge-based rainfall, environmental (temperature, specific humi...

a-Latrotoxin binding to the calcium-independent receptor for a-latrotoxin (CIRL-1), a putative G-protein-coupled receptor, stimulates secretion from chromaffin and PC12 cells. Using patch clamp techniques and microspectrofluorimetry, we demonstrate that the interaction of a-latrotoxin with CIRL-1 produces a high conductance channel that permits increases in cytosolic Ca. a-Latrotoxin interactio...