نتایج جستجو برای: pcdna4
تعداد نتایج: 13 فیلتر نتایج به سال:
The circadian clock links our daily cycles of sleep and activity to the external environment. Deregulation of the clock is implicated in a number of human disorders, including depression, seasonal affective disorder, and metabolic disorders. Casein kinase 1 epsilon (CK1 ) and casein kinase 1 delta (CK1 ) are closely related Ser-Thr protein kinases that serve as key clock regulators as demonstra...
A suppressor tRNATyr and mutant tyrosyl-tRNA synthetase (TyrRS) pair was developed to incorporate 3-iodo-L-tyrosine into proteins in mammalian cells. First, the Escherichia coli suppressor tRNATyr gene was mutated, at three positions in the D arm, to generate the internal promoter for expression. However, this tRNA, together with the cognate TyrRS, failed to exhibit suppressor activity in mamma...
Mutations in genes encoding the human-brain-expressed voltage-gated sodium (NaV) channels NaV1.1, NaV1.2, and NaV1.6 are associated with a variety of human diseases including epilepsy, autism spectrum disorder, familial migraine, other neurodevelopmental disorders. A major obstacle hindering investigations functional consequences brain NaV channel mutations is an unexplained instability corresp...
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