نتایج جستجو برای: pbc

تعداد نتایج: 1663  

Journal: :Gut 1998
J G Kingham D R Parker

BACKGROUND Coexistent primary biliary cirrhosis (PBC) and coeliac disease has been recorded but the association has not been systematically studied. AIMS To determine relative prevalences of PBC and coeliac disease in a defined population over a 12 year period. PATIENTS AND METHODS All patients with PBC or coeliac disease in a stable population of 250,000 in South Wales were identified from...

Journal: :Journal of epidemiology 2006
Fumio Sakauchi Mitsuru Mori Mikio Zeniya Gotaro Toda

BACKGROUND We examined patients who showed laboratory and histological evidence of primary biliary cirrhosis (PBC) in the absence of antimitochondrial antibody (AMA) to elucidate the characteristics of AMA negative PBC. METHODS From a total of 5,805 patients with symptomatic PBC, 2,419 cases (41.7%) were selected in the present study, who were diagnosed using the following criterion; chronic ...

Journal: :Annals of hepatology 2013
Hsuan-Wei Chen Hsin-Hung Huang Ching-Huang Lai Wei-En Chang Yu-Lueng Shih Wei-Kuo Chang Tsai-Yuan Hsieh Heng-Cheng Chu

BACKGROUND AND AIM The aim of this study is to evaluate the role of hepatitis C virus (HCV) infection in patients with primary biliary cirrhosis (PBC). MATERIAL AND METHODS On the basis of a retrospective review of medical records, all patients consecutively diagnosed with PBC or HCV infection between 1999 and 2011 and who had a regular follow-up of at least 3 years were included in the study...

2017
Saeam Shin In Ho Moh Young Sik Woo Sung Won Jung Jin Bae Kim Ji Won Park Ki Tae Suk Hyoung Su Kim Mineui Hong Sang Hoon Park Myung Seok Lee

Primary biliary cholangitis (PBC) is an idiopathic autoimmune liver disease characterized by chronic cholestasis and destruction of the intrahepatic bile ducts. Similar to other autoimmune diseases, the pathogenesis of PBC is considered to be a complex etiologic phenomenon involving the interaction of genetic and environmental factors. Although a number of common variants associated with PBC ha...

Journal: :Fukushima journal of medical science 2006
Hironobu Saito Tsuyoshi Rai Atsushi Takahashi Yukiko Kanno Kyoko Monoe Atsushi Irisawa Hiromasa Ohira

To clarify the clinicolaboratory characteristics of patients with primary biliary cirrhosis (PBC)-autoimmune hepatitis (AIH) overlap, we analyzed their clinicolaboratory findings and compared them with those of patients with AIH or PBC retrospectively. We analyzed the laboratory findings of 177 patients that diagnosed 103 PBC and 74 AIH patients at our department during the period from January ...

2018
Roman Zenouzi Janina von der Gablentz Marcus Heldmann Martin Göttlich Christina Weiler-Normann Marcial Sebode Hanno Ehlken Johannes Hartl Anja Fellbrich Susanne Siemonsen Christoph Schramm Thomas F Münte Ansgar W Lohse

BACKGROUND In primary biliary cholangitis (PBC) fatigue is a major clinical challenge of unknown etiology. By demonstrating that fatigue in PBC is associated with an impaired cognitive performance, previous studies have pointed out the possibility of brain abnormalities underlying fatigue in PBC. Whether structural brain changes are present in PBC patients with fatigue, however, is unclear. To ...

Journal: :Gut 2005
A Jacoby A Rannard D Buck N Bhala J L Newton O F W James D E J Jones

BACKGROUND AND AIMS Study of health related quality of life (HRQOL) and the factors responsible for its impairment in primary biliary cirrhosis (PBC) has, to date, been limited. There is increasing need for a HRQOL questionnaire which is specific to PBC. The aim of this study was to develop, validate, and evaluate a patient based PBC specific HRQOL measure. SUBJECTS AND METHODS A pool of pote...

2017
Agnieszka Kempinska-Podhorodecka Malgorzata Milkiewicz Urszula Wasik Joanna Ligocka Michał Zawadzki Marek Krawczyk Piotr Milkiewicz

Primary biliary cholangitis (PBC) is an immune-mediated cholestatic disease. Vitamin D receptor (VDR)-dependent signaling constrains an inflammatory response by targeting the miRNA155-SOCS1 (suppressor of cytokine signaling 1) axis. The VDR-miRNA155-SOCS1 pathway was investigated in the context of the autoimmune response associated with PBC. Human liver tissues from non-cirrhotic PBC (n = 22), ...

2014
Andreas L. Koutsoumpas Daniel S. Smyk Dimitrios P. Bogdanos

Recurrent urinary tract infections (UTI) have been considered potential triggers of primary biliary cirrhosis (PBC), an autoimmune cholestatic liver disease characterised by progressive destruction of intrahepatic bile ducts. Additional support for the link made between PBC and UTI was based on early observations of recurrent episodes of bacteriuria in female patients with PBC. A series of larg...

2012
Daniel S. Smyk Dimitrios P. Bogdanos Albert Pares Christos Liaskos Charalambos Billinis Andrew K. Burroughs Eirini I. Rigopoulou

Primary biliary cirrhosis (PBC) is a progressive cholestatic liver disease characterised serologically by cholestasis and the presence of high-titre antimitochondrial antibodies, and histologically by chronic nonsuppurative cholangitis and granulomata. As PBC is a granulomatous disease and Mycobacterium tuberculosis is the most frequent cause of granulomata, a causal relation between tuberculos...

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