Structurally well-defined heterogeneous N-glycoclusters are prepared on albumin via a double click procedure. The number of glycan molecules present, in addition to the spatial arrangement of glycans in the heterogeneous glycoclusters, plays an important role in the in vivo kinetics and organ-selective accumulation through glycan pattern recognition mechanisms.

The Scanning Probe Microscopes (SPMs) based lithographic techniques have been demonstrated as an extremely capable patterning tool. Manipulating surfaces, creating atomic assembly, fabricating chemical patterns, imaging topography and characterizing various mechanical properties of materials in nanometer regime are enabled by this technique. In this paper, a qualified overview of diverse lithog...

Among the changeable camouflage patterns of cuttlefish, disruptive patterning is shown in response to certain features of light objects in the visual background. However, whether animals show disruptive patterns is dependent not only on object size but also on their body size. Here, we tested whether cuttlefish (Sepia officinalis) are able to match their disruptive body patterning with increasi...

The complete range of various phyllotaxes exemplified in aquatic plants provide an opportunity to characterize the fundamental geometrical relationships operating in leaf patterning. A new polar-coordinate model was used to characterize the correlation between the shapes of shoot meristems and the arrangements of young leaf primordia arising on those meristems. In aquatic plants, the primary ge...

Camouflage is the primary defense in cuttlefish. The rich repertoire of their body patterns can be categorized into three types: uniform, mottle, and disruptive. Several recent studies have characterized spatial features of substrates responsible for eliciting these body patterns on natural and artificial backgrounds. In the present study, we address the role of spatial scales of substrate text...

Preservation permitting patterns of developmental evolution can be reconstructed within long extinct clades, and the rich fossil record of trilobite ontogeny and phylogeny provides an unparalleled opportunity for doing so. Furthermore, knowledge of Hox gene expression patterns among living arthropods permit inferences about possible Hox gene deployment in trilobites. The trilobite anteroposteri...

Some twenty years ago, Bogen and Woodward challenged one of the fundamental assumptions of the received view, namely the theory-observation dichotomy and argued for the introduction of the further category of scientific phenomena. The latter, Bogen and Woodward stressed, are usually unobservable and inferred from what is indeed observable, namely scientific data. Crucially, Bogen and Woodward c...

7. The story of EZH2, from its discovery as a regulator of body patterning in fruit flies to the recognition of its role as a transcriptional regulator of chromatin structure and as a driver of cancer, should soon have a new chapter once clinical trials reveal whether targeting EZH2 can bring a substantial therapeutic advance. (Kim KH, Roberts CW. Targeting EZH2 in cancer. Nat Med. 2016;22(2):1...

Early patterning of the body during animal development is a fundamental process to subsequent events including cell differentiation, tissue and organ formation, and correct function of the adult body. We focused on two major topics: body segmentation and brain patterning, both of which are essential for conferring a functional complexity to the body, repetition of skeletal elements and complex ...

The Trilobita were characterized by a cephalic region in which the biomineralized exoskeleton showed relatively high morphological differentiation among a taxonomically stable set of well defined segments, and an ontogenetically and taxonomically dynamic trunk region in which both exoskeletal segments and ventral appendages were similar in overall form. Ventral appendages were homonomous biramo...