Patient dosimetry is performed in radiology and interventional radiology to assess whether deterministic injuries may occur and to establish the risk of stochastic effects. A fundamental problem for patient dosimetry is that no single quantity can be used to accurately assess both the risk of stochastic effects and whether deterministic injuries will occur following a specific examination or pr...

Targeted radionuclide therapy holds promise as a new treatment for cancer. Advances in imaging are making it possible for researchers to evaluate the spatial distribution of radioactivity in tumors and normal organs over time. Matched anatomical imaging, such as combined single-photon emission computed tomography/computed tomography and positron emission tomography/computed tomography, has also...

Introduction:The maximum tolerable activity (MTA) of I-131 in radioiodine therapy is an established surrogate quantity to ensure that the therapeutic activity does not produce severe damages to the bone marrow and lung. The aim of this study was to estimate the MTAs for high-risk patients using I-124 pre-therapy dosimetry and to compare the results with published literature. <...

There is a long history of absorbed dose calculations being performed to evaluate the risks involved in the application of radiopharmaceuticals to medical studies. In the 1940s, Marinelli, Quimby, and Hine (1–3) published a set of articles that presented a summary and approach to radionuclide dosimetry. In 1956 Loevinger et al. (4) summarized the field at that point, and then in 1968 the newly ...

UNLABELLED A comprehensive, SPECT-based, patient-specific 3-dimensional (3D) dosimetry analysis has been performed using 3D-ID, a previously developed software package. The role of the total-body tumor burden, individual lesion size, tumor absorbed dose, and the spatial distribution of the absorbed dose on response and on the time course of tumor shrinkage has been examined in patients with lym...

The therapeutic use of radioisotopes in medicine as unsealed sources has a long history dating back to the 1930s. The established and continuing objectives are to provide radiation dose to the target tissue at the desired cytotoxic level while avoiding or minimizing toxic effects. Selected radionuclide therapy protocols including 32P for polycythemia vera, 131I for Graves' disease, and 131I for...

We have constructed a computer controlled translational couch to administer total body irradiation reproducibly and safely. The system has replaced the previous stationary anterior-posterior technique in our institution and 30 plus patients have been treated with it so far. In this technique, patients comfortably lie on a couch in supine and prone positions and are transported slowly through a ...

BACKGROUND Technetium-99m-hydrazinonicotinamide-Tyr3-octreotide (99mTc-HYNIC-TOC) is recognized as a promising radiopharmaceutical for diagnosing neuroendocrine tumors (NETs). However, 99mTc-HYNIC-TOC dosimetry has been investigated only for adults. As pediatric radionuclide therapies become increasingly common, similar dosimetric studies for children are urgently needed. The aim of this study ...

Patient-specific image-based dosimetry is considered to be a useful tool to limit toxicity associated with peptide receptor radionuclide therapy (PRRT). To facilitate the establishment and reliability of absorbed-dose response relationships, it is essential to assess the accuracy of dosimetry in clinically realistic scenarios. To this end, we developed pharmacokinetic digital phantoms correspon...

Dosimetry is the process of calculating the effective radioactive dose that is applied to tumors and organs respectively as a patient undergoes a peptide receptor radionuclide therapy. This work presents the novel application software ‘DoSE8’ that was developed from our group and that incorporates all necessary image processing steps (registration and segmentation) and data handling for (partly...