The following manuscript is mainly conceptual in nature. It should be read with reservation since the relevance of its suggestions have yet to be proven. Basically it proposes two rules for the differentiation between primary illness-related pathophysiological vs. secondary adaptational processes. These rules may guide hypotheses generation for further research that is aimed at understanding ps...

ObjectiveThis study examined the impact of submaximal walking training (WT) on local and systemic nitric oxide (NO) bioavailability, inflammation, oxidative stress in patients with intermittent claudication (IC).MethodsThe employed a randomised, controlled, parallel group design was performed single centre. Thirty-two men IC were randomly allocated to two groups: WT (n = 16, sessions/week, 15 c...