The aim of this study was to determine whether a tapered dosage regimen of paroxetine in pregnant women might be useful to avoid withdrawal syndromes in neonates after delivery. We characterized the transplacental transfer of paroxetine in perfused human placenta, fitting a pharmacokinetic model to the results and applying the model and parameters to evaluate a tapered dosage regimen. Paroxetin...

conclusions the results of the study show that tadalafil can increase the mean ielt and can be used for treatment of premature ejaculation in combination with paroxetine. results the mean age of patients in groups a and b were 33 ± 9.6 and 31.2 ± 9.3 years, respectively (p = 0.368). the mean number of intercourses were 1.08 ± 0.6 and 1.12 ± 0.6 per week in groups a and b, respectively (p = 0.79...

The aim of this study was to determine whether a tapered dosage regimen of paroxetine in pregnant women might be useful to avoid withdrawal syndromes in neonates after delivery. We characterized the transplacental transfer of paroxetine in perfused human placenta, fitting a pharmacokinetic model to the results and applying the model and parameters to evaluate a tapered dosage regimen. Paroxetin...

The aim of the present work was to evaluate influence two different pharmaceutical compounds (bezafibrate and paroxetine) on phytoremediation potential Phragmites australis in an estuarine medium contaminated by copper. Plants were exposed for seven days a simplified medium, elutriate solution, with or without sediment. doped copper bezafibrate paroxetine. P. plants able accumulate significant ...

Paroxetine, a selective serotonin reuptake inhibitor (SSRI), has been reported to have an effect on several ion channels including human ether-a-go-go-related gene in a SSRI-independent manner. These results suggest that paroxetine may cause side effects on cardiac system. In this study, we investigated the effect of paroxetine on Kv1.5, which is one of cardiac ion channels. The action of parox...

A high-performance liquid chromatography (HPLC) method with tandem mass spectrometric detection is described for the determination of paroxetine, an antidepressant drug, and its metabolite (3S,4R)-4-(4-fluorophenyl)-3-(4-hydroxy-3-methoxyphenoxymethyl)piperidine (HM paroxetine) in human plasma. Plasma samples were hydrolysed with hydrochloric acid and then analytes were extracted with ethyl ace...

In order to determine whether paroxetine was associated with any increase in suicidal thoughts or acts all controlled studies of paroxetine were examined in a series of metanalyses. Paroxetine showed an advantage in reducing suicidal thoughts in all analyses compared with placebo. On the MADRS there was a significant advantage compared with active controls at weeks 1, 3, 4 and 6 (P < 0.01). The...

An HPLC method has been developed which enables the quantification of low levels of a catechol derivative and a quinone adduct of paroxetine in the presence of excess drug substance. Due to its inherent instability, the paroxetine quinone adduct is not available as a pure compound so that an indirect method was developed for its quantification. This procedure is based on the assumption that one...

The present study sought to determine whether [3H]paroxetine, a potent and selective inhibitor of serotonin uptake in vitro, could be used to label the serotonin transporter in the rat brain in vivo such that it might be employed to develop a presynaptic serotonergic positron emission tomography ligand. Tritium labeled paroxetine was administered intravenously to rats by means of tail vein inje...

OBJECTIVES Paroxetine has been reported to be useful for management of stuttering symptoms, but only a few reports have examined its effects. We have investigated the efficacy of paroxetine in a randomized, placebo-controlled study. METHODS Five stuttering subjects received paroxetine at 20 mg once daily at night for 12 weeks, and 5 received placebo. The percentages of stuttered words and stu...