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OBJECTIVES/HYPOTHESIS Additional intraoperative guidance could reduce the risk of iatrogenic injury during parotid gland cancer surgery. We evaluated the intraoperative use of fluorescently labeled nerve binding peptide NP41 to aid facial nerve identification and preservation during parotidectomy in an orthotopic model of murine parotid gland cancer. We also quantified the accuracy of intraoper...

Cancer of the parotid gland is relatively rare, but carries poor prognosis owing to its prevailing distant metastases. In addition to the disease's basic epidemiology and pathology, we review some current discoveries of its tumorigenesis molecular mechanism. Based on published salivary gland cancer clinical trial data, non-surgical antitumor efficacies amongst a range of chemotherapy, radiation...

Parotid gland cancer; 3DCRT; Postoperative radiotherapy techniques; Dose distribution Abstract Introduction: Postoperative radiotherapy of the parotid gland could be achieved with various radiotherapy techniques. However they irradiate differently the surrounding organs at risk (OARs) in particular the cochlea, oral cavity & contralateral parotid causing significant increase in the risk of oral...

Introduction: Background: Radiotherapy of parotid tumors is achieved by different radiotherapy techniques. So they deliver the dose to organs at risk such as contralateral parotid, temporal lobe & spinal cord. The consequences of high dose to OARs are xerostomia, Temporal lobe necrosis and loss of hearing. Purpose: The aim of this study was to compare different treatment tech...

introduction: mucoepidermoid carcinoma represents one of the most common malignant salivary gland tumors.however, the sclerosing morphologic variant is extremely rare with only 23 reported cases in the english-language literature since it was discovered in 1987. case report: herein, we describe another case that was diagnosed in a 25-year-old woman presenting with a posterior auricular mass, as...

BACKGROUND Carcinoma ex pleomorphic adenoma (CXPA) of the parotid gland is a high-grade cancer and the prognosis of this cancer has not been compared with non-CXPA high-grade primary parotid cancer. METHODS Retrospective medical chart review of patients with surgically treated high-grade primary parotid cancer (21 CXPA and 52 non-CXPA) was performed with correlation with disease-specific surv...

Introduction Parotid gland squamous cell carcinoma is an uncommon aggressive neoplasm with poor prognosis. Aural polyps are usually the presenting features of chronic suppurative otitis media, tuberculous otitis media, and adenoma or carcinoma. The malignant aural polyp is very rare. Parotid gland carcinoma masquerading as an aural polyp has rarely been described in the literature. ...

BACKGROUND Parotid gland metastasis in lung cancer is extremely rare, very few cases have been reported. CASE PRESENTATION We report on the case of a 61-year-old Chinese male patient who presented with parotid swelling metastasizing from advanced lung cancer. We therefore performed an operation of partial parotidectomy with preservation of the facial nerve and advised the patient receive chem...

BACKGROUND AND PURPOSE Although radiation induced damage to the salivary gland is a known complication of radioactive iodine ((131)I) therapy for thyroid carcinoma, prediction of the severity and reversibility of sialoadenitis is difficult. Our aim was to correlate the extent of salivary dysfunction assessed by salivary gland scintigraphy with changes in the volume and attenuation of salivary g...