The paper details the construction of a clinical decision support system which is the integral part of the ParkinsonCheck application. ParkinsonCheck is an app for smart phones built to detect signs of Parkinsons disease (PD) and essential tremor (ET), which is the main differential diagnosis from PD in the early stage of the disease. The application is based on spirography (spiral drawing) and...

INTRODUCTION Neuroimaging studies of elderly individuals reveal alterations in the white matter that are incompatible with the patients parkinsonism, mistakenly classified as vascular parkinsonism (VP). METHOD This study was conducted on a population composed of 20 patients with Parkinsons disease (PD) whose neuroimaging exams revealed vascular alterations in the white matter and seven patien...

BACKGROUND Dizziness is a frequent complaint of patients with Parkinson's disease (PD), and orthostatic hypotension (OH) is often thought to be the cause. We studied whether benign paroxysmal positional vertigo (BPPV) could also be an explanation. AIM To assess the prevalence of benign paroxysmal positional vertigo in patients with Parkinson's disease, with and without dizziness. METHODS 30...

Apomorphine and certain ergot alkaloids (bromocriptine, lisuride and pergolide) have been available for several decades; for the last few years, they were joined by newer dopamine agonists (cabergoline, pramipexole and ropinirole) most of them are non-ergolines. Each of these dopamine agonists has its own pharmacological characteristics and occupies a place in the pharmacotherapy of Parkinsons ...

Despite Medicare data showing that about 25% of people with Parkinson’s disease (PD) reside in nursing homes, many practitioners may not have a lot experience diagnosing and managing this condition. As Nora Reznickova, MD, geriatrician at Colorado Permanente Medical Group Boulder, said, “Starting the differential diagnosis, aren’t necessarily comfortable PD patients. They feel like they necessa...

Deep brain stimulation (DBS) has been widely used to control motor symptoms and improve quality of life in patients with Parkinsons disease (PD). Recently, DBS in the subthalamic nucleus (STN) has become the preferred target for patients with mixed motor symptoms. Despite resultant motor and quality of life improvements, the procedure has been associated with cognitive decline, mainly in langua...

Parkinsons disease (PD) is the second most prevalent neurodegenerative disorder after Alzheimer’s, affecting about 1% of the people older than 65 and about 89% of the people with PD develop different speech disorders. Different researchers are currently working in the analysis of speech of people with PD, including the study of different dimensions in speech such as phonation, articulation, pro...

Objective: The aim of this study is to develop a smartphone-based high-frequency remote monitoring platform, assess its feasibility for remote monitoring of symptoms in Parkinsons disease, and demonstrate the value of data collected using the platform by detecting dopaminergic medication response. Methods: We have developed HopkinsPD, a novel smartphonebased monitoring platform, which measures ...