OBJECTIVE To measure the promptness of antibiotic treatment in children with meningococcal disease. METHODS "Door to needle time" for parenteral antibiotics in children with meningococcal disease was recorded prospectively as part of a larger study. The time from arrival at hospital until the first dose of parenteral antibiotics was recorded in 100 children with meningococcal disease (median ...

Concern about serious bacterial infection is a common reason for children to be admitted to hospital, many of whom are given parenteral antibiotics. Once children are converted to oral antibiotics, they are usually discharged home, so the length of parenteral antibiotic treatment is a major determinant of length of stay and total cost of care (unless children can be discharged home on outpatien...

BACKGROUND Pediatric osteomyelitis is a bacterial infection of bones requiring prolonged antibiotic treatment using parenteral followed by enteral agents. Major complications of pediatric osteomyelitis include transition to chronic osteomyelitis, formation of subperiosteal abscesses, extension of infection into the joint, and permanent bony deformity or limb shortening. Historically, osteomyeli...

in order to ensure the safety of parenterals, international pharmacopoeias and national standards have set up stringent guidelines and standards. particulate con- tamination is a potential health risk caused by intravenous injection of particles large enough to potentially clog the small arteries. particles could be produced through manufacturing and packaging or even dispensing of the pharmace...

BACKGROUND Survival from early meningococcal disease might be improved if general practitioners followed guidelines by immediately administering parenteral antibiotics (before hospital referral). METHODS Structured telephone interviews with 20 GPs who had previously treated meningococcal cases. RESULTS General practitioners knew guideline recommendations for early management of meningococca...

OBJECTIVE To measure the effect of parenteral antibiotics given before admission to hospital on mortality and on bacteriological investigations in meningococcal disease. DESIGN Retrospective review of hospital notes and laboratory and public health medicine department records. SETTING Three health districts in south west England. SUBJECTS Patients with meningococcal disease in Gloucester ...

The standard recommendation for treating chronic osteomyelitis is 6 weeks of parenteral antibiotic therapy. However, oral antibiotics are available that achieve adequate levels in bone, and there are now more published studies of oral than parenteral antibiotic therapy for patients with chronic osteomyelitis. Oral and parenteral therapies achieve similar cure rates; however, oral therapy avoids...

The choice of administration route for an antibiotic remains a fairly controversial matter, as confirmed by the variation in prescribing habits among different countries. This variation may result from difficulty in identifying standard criteria that would unequivocally indicate the necessity of oral or parenteral administration. 1 In general, the decision to administer an antibiotic by the par...

Validation process is a program for ensuring products with proven acceptable and predetermined specification. The LAL test used for detection of endotoxin in the sterile parenteral products is one of the tests that require validation. During this study, validation of 12 parenteral antibiotics including penicillin and cephalosporin have been done using gel clot method and obtained results which ...