Parathyroid carcinoma is an infrequent cause of primary hyperparathyroidism. Although hyperparathyroidism in multiple endocrine neoplasia 1 (MEN1) syndrome is the most common manifestation, parathyroid carcinoma is rare. We report a male patient who was diagnosed at 44 years of age with parathyroid carcinoma in the context of MEN1 syndrome coincident with a malignant gastrinoma and non-function...

Parathyroid carcinoma is a rare endocrine neoplasm that accounts for <1% of cases primary hyperparathyroidism. The management parathyroid challenge due to the high rate local recurrence tumour. We report case middle-aged north Indian woman who presented with recurrent hyperparathyroidism carcinoma. She palpable hard neck mass and underwent radical dissection six times. At time writing this r...

conclusions the recurrence of hyperparathyroid hypercalcemia in htp-jt syndrome after an initial total parathyroidectomy is a well-known condition necessitating careful management, an evaluation of any underlying genetic abnormality, and a family examination. a surgical treatment and surveillance of calcium and pth measurements are necessary to prevent a recurrence. introduction cancer in the p...

BACKGROUND Parathyroid carcinoma, atypical parathyroid adenoma, and parathyromatosis can be differentiated relatively easily from typical parathyroid adenomas, but distinguishing them from each other is more difficult. METHODS A retrospective study of 28 consecutive patients with parathyroid carcinoma, 7 patients with atypical parathyroid adenoma, and 13 patients with parathyromatosis who wer...

CONTEXT AND OBJECTIVE Adequate management of parathyroid carcinoma apparently relates to the surgeons ability to identify it at the first operation. The objective of this paper was to evaluate the role of clinical suspicion in the management of parathyroid carcinoma. DESIGN AND SETTING Retrospective analysis of parathyroid carcinoma patients treated in Department of Head and Neck Surgery, Fac...

Introduction: Although co-occurring thyroid pathologies are common in patients with primary hyperparathyroidism, synchronous parathyroid and differentiated thyroid carcinoma is a rare situation. Case: A 65-year-old woman presented to our endocrinology clinic for evaluation of hypercalcemia. She had an albumin-corrected serum calcium (Ca) concentration of 12.4 mg/dl (normal, 8.6-10 mg/dl), serum...

Parathyroid carcinoma is a rare malignancy, and only accounts for 0.5-2% of cases of primary hyperparathyroidism. Less than 10% of parathyroid carcinomas are non-functional, and as such, they have been rarely reported in the literature. Importantly, margin status at resection is related to prognosis, and only a handful of case reports of non-functional carcinoma note this important parameter. H...

OBJECTIVE To describe a patient presenting with the rare constellation of synchronous parathyroid carcinoma, parathyroid adenoma, and papillary thyroid carcinoma. METHODS We summarize the clinical presentation, diagnostic work-up, surgical management, and pathologic features of our patient and review the pertinent literature. RESULTS The patient was a 59-year-old man who presented with seve...

Parathyroid carcinoma is an indolent but ultimately life-threatening malignancy. Due to the lack of definitive diagnostic markers and overlapping clinical features of benign primary hyperparathyroidism (PHPT), this disease is often misdiagnosed as parathyroid adenoma. Therefore, a high index of suspicion preoperatively and early intraoperative recognition with en bloc surgical resection are cru...

Mutations of the HRPT2 gene, which are responsible for hyperparathyroidism-jaw tumor (HPT-JT) syndrome, have been implicated in the development of a high proportion of parathyroid carcinomas. The aim of this study was to investigate differences in expression of the most important genes connected with parathyroid carcinoma between HPT-JT syndrome due to an HRPT2 splicing mutation, normal parathy...