Background: Paraquat (PQ), an herbicide, is a very poisonous compound for both humans and animals. This study was conducted to examine the protective effect of the Coenzyme Q10 (CoQ10) in newborn rats from pregnant rats pre-treated with PQ. Methods: The experiments were conducted on 25 rats, divided in five groups randomly and equally: 1 - Control Group received normal saline (0.1ml/day); 2...

paraquat (pq) is a widely used herbicide. however, a large number of cases of accidental or suicidal poisoning from pq has been reported. membrane damage induced by lipid peroxidation, inactivation of protein or damage to dna by radical formation have been suggested as toxicity mechanisms of pq. in the present work, the effects of atropine, propranolol, procainamide and dipyridamole on pq-induc...

Paraquat (PQ) is a widely used herbicide. However, a large number of cases of accidental or suicidal poisoning from PQ has been reported. Membrane damage induced by lipid peroxidation, inactivation of protein or damage to DNA by radical formation have been suggested as toxicity mechanisms of PQ. In the present work, the effects of atropine, propranolol, procainamide and dipyridamole on PQ-...

Experimental evidence supporting 1,1'-dimethyl-4,4'-bipyridinium [paraquat (PQ)] as a risk factor for Parkinson's disease (PD) is equivocal. Other agricultural chemicals, including dithiocarbamate fungicides such as manganese ethylenebisdithiocarbamate [maneb (MB)], are widely used in the same geographical regions as paraquat and also impact dopamine systems, suggesting that mixtures may be mor...

OBJECTIVE To study ultra-early pathophysiological changes of rabbit acute lung injury (ALI) caused by paraquat (PQ) and discuss the ultra-early protective effect of ulinastatin on rabbit ALI due to PQ. METHODS 30 New Zealand white rabbits were randomly divided into a control group, a paraquat group and an ulinastatin intervention group with 10 rabbits in each group. For paraquat group and int...

We described and analyzed the treatment process of an HIV-positive patient with severe paraquat (PQ) poisoning. A 34-year-old man ingested about 50 mL of a 20% solution of PQ in a suicide attempt. He was treated with gastric lavage, oral administration of adsorbent, and symptomatic treatments at the local hospital, and was transferred to our emergency department. Ten hours after the exposure, t...

Paraquat (PQ) has been demonstrated that the main target organ for the toxicity is the lung. This study aimed to investigate the potential protective effect of PDTC on the PQ-induced pulmonary damage. Fifty-four rats were divided into control, PQ-treated and PQ+PDTC-treated groups. Rats in the PQ group were administrated 40 mg/kg PQ by gastric gavage, and PDTC group with 40 mg/kg PQ followed by...

Parkinson's disease (PD) is a neurodegenerative disorder characterized by fibrillar cytoplasmic aggregates of α-synuclein (i.e., Lewy bodies) and the associated loss of dopaminergic cells in the substantia nigra. Mutations in genes such as α-synuclein (SNCA) account for only 10% of PD occurrences. Exposure to environmental toxicants including pesticides and metals (e.g., paraquat (PQ) and manga...

The continuous infusion of taurine markedly protected against paraquat (PQ)-induced oliguria in beagles. Pharmacokinetic studies revealed that taurine infusion increased the blood concentration of PQ and reduced the net content in the kidney and, to a lesser extent, in the lung. The excretion of PQ into the urine was unaltered. The infusion of glycine did not have such effects.

edaravone, an antioxidant and radical scavenger, showed protective effects against oxidative stress-like condition. paraquat (pq) is a toxic herbicide considerable evidence suggests that oxidative stress and mitochondrial dysfunction contribute to pq toxicity. in this study, protective effect of edaravone against pq induced toxicity and reactive oxygen species (ros) generation in a549 cells and...