INTRODUCTION It has been reported by Morris et at. (6, 7) that dietary pantothenic acid deficiency retarded the growth of spontaneous mammary tumors in mice (C3H strain). This result is in contrast to the find ings of Bischoff et a!. (@) who found no retardation of growth of Sarcoma 180 transplanted into Marsh-Buffalo mice on a similar pantothenic acid deficient diet. Although different tumors ...

A relationship between pantothenic acid and the adrenal gland has been evident since the earliest work with this vitamin was done. Morgan and Simms (1) found pathologic changes in the adrenals of rats on diets free from “filtrate factor,” and reported (2) that the achromotrichia of rats maintained on these diets could be at least partly reversed by extracts of the thyroid and of the adrenal cor...

Before the nature of “bound” pantothenic acid was established, McIlwain and Hughes (1) showed that incubation of pantothenic acid with various streptococci or Proteus morganii led to its “inactivation” as a growth factor for these organisms. This inactivation reaction was dependent upon glycolysis, but independent of growth and the presence of oxygen, and was inhibited by pantoyltaurine (2). Mc...

Before the nature of “bound” pantothenic acid was established, McIlwain and Hughes (1) showed that incubation of pantothenic acid with various streptococci or Proteus morganii led to its “inactivation” as a growth factor for these organisms. This inactivation reaction was dependent upon glycolysis, but independent of growth and the presence of oxygen, and was inhibited by pantoyltaurine (2). Mc...

Description Pantothenic acid (vitamin B5) is a water-soluble B-complex vitamin that was identi!ed in 1933, isolated and extracted from liver in 1938, and !rst synthesized in 1940.1 R. J. Williams is credited with coining the name from the Greek word panthos, which translates as “from everywhere.” It was given this name because of its widespread presence in food.2 Most vitamin B5, and its deriva...

Three senile patients developed fatal acute encephalopathy while receiving calcium hopantenate. The clinical, biochemical, and pathological picture was similar to Reye's syndrome. Calcium hopantenate is a pantothenic acid antagonist. The serum levels of calcium hopantenate were high in coma, and that of pantothenic acid examined in one patient was lowered. Evidence obtained indicated that the R...

Results of studies on pantothenic acid-deficient rats stimulated with anterior pituitary growth hormone (l-3) suggest involvement of pantothenic acid, or its metabolically active form, coenzyme A (4), in the mechanism by which growth hormone stimulates the growth process. Lotspeich (l), for example, describes the rapid production of symptoms of acute pantothenic acid deficiency as a sequel to t...