The possibility of an interaction between diazepam and pancuronium bromide was investigated in six patients undergoing general anaesthesia maintained with fentanyl, droperidol and nitrous oxide. Neuromuscular blockade was controlled using a feedback mechanism which automatically adjusted the rate of injection of pancuronium to maintain between 71.4 and 72.9% blockade. Diazepam 0.14 mg kg-1 i.v....

The effect of pancuronium bromide on the canine myocardium was studied by observing several indices of myocardial contractility during i.v. and intracoronary infusion of the drug in an anaesthetized, open-chested dog preparation. Pancuronium produced tachycardia when given for 2 min by i.v. and intracoronary infusion with the heart intact. Following denervation and pacing of the heart the intra...

We report three infants paralysed with pancuronium bromide as an adjunct to mechanical ventilation, who developed multiple joint contractures. In two term infants, gentamicin and phenobarbitone given together with pancuronium may have potentiated its effect, and in one preterm infant contractures, which became more severe after paralysis, were present at birth.

Atropine (0.04 mg/kg) was given half an hour before the operation by intramuscular injection. Anaesthesia was induced using 10 per cent halothane in an oxygen and nitrous oxide mixture (4 l./min of each) via a Magill circuit, using a Hall dog mask. After intubation, pancuronium bromide (0.13 mg/kg) was given by intravenous injection and anaesthesia was maintained with a mechanical ventilator us...

stan-2b ,16b-ylene)bis(1-methyl-piperidinium) dibromide [15500-66-0] is general anaesthesia used in surgery for muscle relaxation and as an aid to endotracheal intubation (Chart 1). Several methods of determination of this drug have been reported in the literature, including high performance liquid chromatography (HPLC), capillary gas chromatography using nitrogen sensitive detection, liquid ch...

Calf muscle blood flow was measured in eight patients with confirmed ischaemic disease of their lower limbs, before and during general anaesthesia which included pancuronium bromide and intermittent positive pressure ventilation. Anaesthesia was associated with a decrease in limb blood flow. Comparison of these results with those of a similar study in which tubocurarine was employed in a place ...

An i.v. bolus and concomitant infusion of pancuronium is proposed for use in prolonged anaesthesia. Plasma concentrations of pancuronium were measured in 16 patients receiving this regime. The desired steady-state concentration of 0.2 fig ml" was achieved in most instances at approximately 45 min. Following the bolus, the neuromuscular twitch response decreased to low values or was abolished co...