aim : the aim of this study was to assay the most common signs, symptoms, and positive paraclinical findings in pancreatic cancer. background : it seems that the most available method for early diagnosis of pancreatic cancer is using clinical history and especially appearance of early signs and symptoms. patients and methods : in this descriptive study, all pancreatic cancer patients referred t...

background pancreatic cancer (pc) is classified as one of the most deadly cancers. since the role of diet in modifying the effects of known risk factors of pc has been well established, exploring the dietary intakes in relation to the etiology of pc can be useful for elucidating the mechanisms of the disease progression. methods and materials this study was conducted within the golestan prospec...

background there are hoarding documents for the biological importance of cyclooxygenase-2 (cox-2) in pancreatic carcinogenesis. we aimed to thoroughly investigate the dna sequence variations of whole cox-2 exons in a large case-control study of pancreatic cancer by direct sequencing.   methods the entire exonic regions of cox-2 including 10 exons were sequenced in the germline dna of 96 patient...

background: cancer is a major public health problem and one of the leading causes of death worldwide. lifestyle factors including dietary patterns are a major determinant of increasing rates of cancer. sugar-sweetened beverages (ssbs) have recently received great attention due to their effects on hyperglycemia, hyperinsulinemia, reduced insulin sensitivity, and obesity as well as their probable...

background : pancreatic cancer is a major worldwide health problem. little is known about the etiology of pancreatic cancer, which is an important cause of cancer mortality in developed countries. this study evaluates the importance of amounts of trace elements in pancreatic cancer etiology and diagnostics. methods : atomic absorption spectrometry was used to estimate zinc, selenium, copper, ca...

Introduction : Severepain is a major problem in patients with unresectable pancreatic cancer. The goal of this study is to evaluate the effects of Thoracoscopic Splanchnicectomy (TS) on pain control in these patients suffering from unresectable pancreatic cancer. Methods:Between years 2000 to 2011, 20 patients suffering from unresectable pancreatic cancer underwent TS due to severe pain. They w...

The effect of p53 gene therapy on chemosensitivity and apoptotic response of PANC-1 tumor cells, which express high amount of mutant p53, to cancer chemotherapeutic agents of Etoposide and Doxorubicin was investigated. Comparison of the chemosensitivity of PANC-1 cells to its wild type p53 transfectants showed that wt-p53 expressing transfectants are more sensitive to both Etoposide and Doxorub...

pancreatic neuroendocrine tumors (pnet) are uncommon pancreatic neoplasms, accounting for 1-2% of all pancreatic tumors. however, they have a better prognosis and long-term survival compared to exocrine pancreatic cancer. pnets can be divided into functional or non-functional based upon whether or not they excrete active substances relevant to specific clinical syndromes. skeletal muscle metast...