نتایج جستجو برای: pancreatic β cell

تعداد نتایج: 1877157  

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2015
Naureen Javeed Gunisha Sagar Shamit K Dutta Thomas C Smyrk Julie S Lau Santanu Bhattacharya Mark Truty Gloria M Petersen Randal J Kaufman Suresh T Chari Debabrata Mukhopadhyay

PURPOSE Pancreatic cancer frequently causes diabetes. We recently proposed adrenomedullin as a candidate mediator of pancreatic β-cell dysfunction in pancreatic cancer. How pancreatic cancer-derived adrenomedullin reaches β cells remote from the cancer to induce β-cell dysfunction is unknown. We tested a novel hypothesis that pancreatic cancer sheds adrenomedullin-containing exosomes into circu...

2017
Jingjing Wang Hongjun Wang

Pancreatic β cell neogenesis and proliferation during the neonatal period are critical for the generation of sufficient pancreatic β cell mass/reserve and have a profound impact on long-term protection against type 2 diabetes (T2D). Oxidative stress plays an important role in β cell neogenesis, proliferation, and survival under both physiological and pathophysiological conditions. Pancreatic β ...

2013
Terri N. Iwata Timothy J. Cowley Michael Sloma Yewei Ji Hana Kim Ling Qi Siu Sylvia Lee

The transcriptional co-regulator host cell factor-1 (HCF-1) plays critical roles in promoting cell cycle progression in diverse cell types, and in maintaining self-renewal of embryonic stem cells, but its role in pancreatic β-cell function has not been investigated. Immunhistochemistry of mouse pancreas revealed nuclear expression of HCF-1 in pancreatic islets. Reducing HCF-1 expression in the ...

Journal: :Cell 2013
Peng Yi Ji-Sun Park Douglas A. Melton

Replenishing insulin-producing pancreatic β cell mass will benefit both type I and type II diabetics. In adults, pancreatic β cells are generated primarily by self-duplication. We report on a mouse model of insulin resistance that induces dramatic pancreatic β cell proliferation and β cell mass expansion. Using this model, we identify a hormone, betatrophin, that is primarily expressed in liver...

2015
Yi Lin Zhongjie Sun

Protein expression of an antiaging gene, Klotho, was depleted in pancreatic islets in patients with type 2 diabetes mellitus (T2DM) and in db/db mice, an animal model of T2DM. The objective of this study was to investigate whether in vivo expression of Klotho would preserve pancreatic β-cell function in db/db mice. We report for the first time that β-cell-specific expression of Klotho attenuate...

2016
Sam Tsz Wai Cheng Lihua Chen Stephen Yu Ting Li Eric Mayoux Po Sing Leung Angel Nadal

The novel sodium glucose co-transporter 2 (SGLT2) inhibitor empagliflozin has recently been reported to improve glycemic control in streptozotocin-induced type 1 diabetic rats in an insulin-independent manner, via an increase in urinary glucose output. We investigated the potential of empagliflozin to recover insulin pathways in type 1 diabetes by improving pancreatic β-cell mass. Blood glucose...

Background Considering the increasing prevalence of type 1 diabetes mellitus (T1DM) as an autoimmune disease in recent years and the positive effects of vitamin D (VD) on this disease, especially the preventive effect of VD on progressive reduction of pancreatic β-cells, we aimed to investigate the effect of VD on pancreatic β-cell function in T1DM patients. Materials and Methods From Sep 2016 ...

2013
Tomoyuki Suzuki Ping Dai Tomoya Hatakeyama Yoshinori Harada Hideo Tanaka Norio Yoshimura Tetsuro Takamatsu

Proliferation of pancreatic β-cells is an important mechanism underlying β-cell mass adaptation to metabolic demands. Increasing β-cell mass by regeneration may ameliorate or correct both type 1 and type 2 diabetes, which both result from inadequate production of insulin by β-cells of the pancreatic islet. Transforming growth factor β (TGF-β) signaling is essential for fetal development and gro...

Journal: :American journal of physiology. Endocrinology and metabolism 2014
Maria L Golson William S Bush Marcela Brissova

β-Cell mass is a parameter commonly measured in studies of islet biology and diabetes. However, the rigorous quantification of pancreatic β-cell mass using conventional histological methods is a time-consuming process. Rapidly evolving virtual slide technology with high-resolution slide scanners and newly developed image analysis tools has the potential to transform β-cell mass measurement. To ...

Journal: :Pathobiology : journal of immunopathology, molecular and cellular biology 2015
Shymi Kumaran K S Samantha Devaraj Halagowder

BACKGROUND It is not clear by which mechanism nuclear factor-kappaB (NFκB) induces cell proliferation and escapes from the apoptotic pathway in pancreatic carcinogenesis. This study aimed to investigate β-catenin and NFκB signalling in chronic pancreatitis and pancreatic cancer. MATERIALS AND METHODS On tissue samples of chronic pancreatitis and pancreatic cancer, we performed immunohistochem...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید