Starting from γ-ketoesters with an o-iodobenzyl group we studied a palladium-catalyzed cyclization process that stereoselectively led to bi- and tricyclic compounds in moderate to excellent yields. Four X-ray crystal structure analyses unequivocally defined the structure of crucial cyclization products. The relative configuration of the precursor compounds is essentially transferred to that of ...

nowadays, palladium compounds due to their especial characteristics used in different industries, mainly in electrical power sources and chemical productions as a catalyst. therefore, pd concentration is increasing in our around that can be contaminant our environment due its toxic effects. in this work, a simple, selective and rapid flow injection method of analysis (fia) has been developed fo...

It was previously reported that the palladium-catalyzed cross-coupling reaction of 1-alkenylboron compounds with various vinylic or aryl halides in the presence of base provides the corresponding coupling products in high yields, stereoand regioselectively. The recent progress of such reactions, including the reaction of sterically hindered arylboronic acids with sterically hindered haloarenes,...

A ligand free, Palladium nanoparticles catalyzed synthesis of pyran derivatives using C-H activated compound, malononitrile and aryl aldehyde via Knoevenagel condensation followed by Michael addition reaction using Palladium nanoparticles as catalyst in one-pot is described herein. The advantages of this method lie in its simplicity, low catalyst loading, cost effectiveness and easy to handle. ...

PURPOSE As novel therapeutic agents relevant to colon cancer therapy are explored continuously, we tested 4 R2edda-type ligand precursors O,O'-dialkyl esters of (S,S)-ethylenediamine-N,N'-di-2-(4-methyl)pentanoic acid (L1.2HCl-L4.2HCl) and corresponding palladium(II) and platinum(II) complexes against the human colon cancer cell lines CaCo-2, SW480 and HCT116. METHODS The effects of the teste...

The palladium (II)-catalysed reactions of alkenols and aminoalkenols such as oxycarbonylations or bicyclisations are powerful methods for the construction of oxygen and nitrogen-containing heterocyclic compounds. This review highlights recent progress in the development of the asymmetric palladium(II)-catalysed Wacker-type cyclisations of unsaturated polyols and aminoalcohols. The scope, limita...

Abstract: Aryl halides and aryl triflates (triflate = trifluoromethanesulfonyl) are coupled with N-compounds to give the corresponding arylamines or arylhydrazines in the presence of a palladium catalyst, a suitable ligand, and a base. Catalyst systems consisting of palladium (II) and BINAP or triphenylphosphine are generally effective for the amination of a wide range of aryl halides and aryl ...

A new series of palladium sensors based on fluorescein bis(allyl ether) compounds has been designed. We utilized reduced fluoresceins as key synthetic intermediates. These probes exhibit negligible background fluorescence and rapid reaction with palladium, allowing a concentration of <100 ppt to be detected in minutes using a handheld UV lamp.

The palladium-catalysed intramolecular α-arylation of carbonyl compounds with amino-tethered 2- and 3-iodoindoles provides a useful methodology for the synthesis of indolo-b-fused nitrogen heterocycles. A variety of substituted tetrahydro β- and γ-carbolines, and pyrrolo[3,4-b]indoles, have been prepared by means of this palladium-catalysed annulation process.

New benzimidazolium salts 1a-c and their palladium bis-N-heterocyclic carbene complexes 2a-c and palladium PEPPSI-type complexes 3a-c were designed, synthesized and structurally characterized by NMR (1H and 13C), IR, DART-TOF mass spectrometry and elemental analysis. Then these complexes 2-3 were employed in the Suzuki-Miyaura cross-coupling reaction of substituted arenes with phenylboronic aci...