BACKGROUND Preemptive analgesia is an antinociceptive treatment that prevents central sensitization. Antinociceptive effects of diclofenac are well-known. The aim of this study was to investigate preemptive analgesic effects of intraperitoneally administrated diclofenac, before and after acute and inflammatory induced pain in rat model. METHODS Forty eight male Sprague Dawley rats were includ...

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background and aims: osteoarthritis is one of the most common arthritis in elderly. we evaluated to compare the effect of topical application of eugenia caryophylata extract and topical diclofenac in primary knee osteoarthritis.methods: this randomized double-blind clinical trial study was carried out upon 105 patients with primary knee osteoarthritis. patients were selected randomly and divide...

conclusions totally, according to the obtained results it may be concluded that paracetamol and diclofenac combination would have a better efficacy in postoperative pain control and need reduction to additive analgesia compared to meperidine. patients and methods one hundred and twenty women candidates for elective cesarean section under spinal anesthesia categorized as asa class i were selecte...

conclusions the use of diclofenac suppository combined with iv pca results in reduced narcotic usage and a higher level of patient satisfaction compared to the use of iv acetaminophen combined with iv pca. results the patients’ characteristics were the same in both study groups. the patients’ satisfaction levels were higher among those who received diclofenac when compared with the acetaminophe...

conclusions in this study, intravenous paracetamol or diclofenac suppositories, administered for postgastrectomy pain control, decreased morphine consumption by almost 32% and also improved alertness. nevertheless, the amount of opioids did not affect the incidence of complications. background major surgical procedures, such as gastrectomy, result in extensive postoperative pain, which can lead...

the present study was performed to investigate the effects of long-term intraperitoneal (ip) injection of vitamin b12 and diclofenac in separate and combined treatments on cold and mechanical allodynia in a neuropathic pain model in rats. neuropathic pain was induced by crush injury in right tibial nerve. acetone spray and von frey tests were used to obtain cold and mechanical allodynia respons...

background the aim of the present study was to compare two analgesic techniques for transrectal ultrasound (trus)-guided biopsy: diclofenac patch versus periprostatic nerve block with 1% lidocaine. objectives to study the efficacy of and compare diclofenac patch and periprostatic nerve block as analgesia in trus-guided prostate needle biopsy. patients and methods in total, 60 patients were pros...

conclusions both morphine and diclofenac suppositories reduced pain significantly and similarly after cabg surgery. results no significant statistical relationship was found between the two groups regarding gender, age, bmi, paracetamol consumption, length of operation time, cardiopulmonary bypass pump (cpb) time, and stay time at icu (p value ≥ 0.05). total dosage of used morphine was 22 ± 8.3...

pain, particularly after surgery, can create a variety of side effects including delay in wound healing. different drugs such as pethidine and non-steroidal anti-inflammatory drugs are used for relieving patient's pain after surgery. the purpose of this research was to compare effect of pethidine vs. diclofenac (d) suppository in relief of pain after laminectomy. a total of 100 patients who und...