نتایج جستجو برای: pai
تعداد نتایج: 6649 فیلتر نتایج به سال:
زمینه و هدف: سویههای اشریشیاکلی ایجادکنندۀ عفونت دستگاه ادراری، دارای جزایر حاوی ژنهای کدکنندۀ فاکتورهای حدت هستند. اطلاعات کمی دربارۀ نوع و چگونگی توزیع این جزایر در گروههای فیلوژنی اشریشیاکلی مولّد عفونتهای ادراری در مناطق مختلف ایران وجود دارد. در این مطالعه، چگونگی توزیع جزایر حاوی ژنهای کدکنندۀ فاکتورهای حدت بین گروههای فیلوژنی ایزولههای اشریشیاکلی جداشده از بیماران مبتلا به عفونت...
The inactivation of plasminogen activator inhibitor-1 (PAI-1) by the small molecule PAI-1 inhibitor PAI-039 (tiplaxtinin) has been investigated using enzymatic analysis, direct binding studies, site-directed mutagenesis, and molecular modeling studies. Previously PAI-039 has been shown to exhibit in vivo activity in various animal models, but the mechanism of inhibition is unknown. PAI-039 boun...
مقدمه: گزارش شده پلی مورفیسم شایع4g/5g در پروموتر ژن مهارکننده فعال کننده پلاسمینوژن-1(pai-1) در سطح بیان pai-1 تأثیر دارد و با توجه به شواهدی که پیشرفت سرطان پستان را با افزایش سطح pai-1 همراه می داند، ارزیابی ارتباط بین این پلی مورفیسم و وضعیت بالینی بیماران مبتلا به سرطان پستان معقول و منطقی به نظر می رسد. روش بررسی: این مطالعه توصیفی- تحلیلی شامل 160 بیمار غیرخویشاوند از جمعیت شمال غرب ایرا...
objective: in 1993, muller developed the prenatal attachment inventory (pai) which has been used widely in many studies and translated into several languages. the current study aimed to translate the pai into persian, assess the underlying structure of the pai, and the appropriateness of the one-factor solution proposed by muller. materials and methods: in this cross-sectional study, we recruit...
Background: Menopause is a unique event in women's life it usually occurs naturally, most often after age 50 when woman has not menstruated in 12 consecutive months. This study was planned to assess the relationship between Vitamin D3 level, PAI-1 and HCG in Babylon women at age <50 years as pre-menopausal and> 50 years as post-menopausal. Methods: The sample were selected from a group of p...
A diacid monomer was synthesized by the condensation of L-tryptophan amino acid and pyromellitic dianhydride (PMDA). The diacid was utilized for the synthesis of three types of poly(amide-imide)s (PAIs) using three different kinds of diamines. The synthesized monomer and PAIs were characterized using FT-IR, 1H-NMR and 13C-NMR spectroscopies and the PAIs were also used ...
Administration of a mutant, noninhibitory PAI-1 (PAI-1R), reduces disease in experimental glomerulonephritis. Here we investigated the importance of vitronectin (Vn) binding, PAI-1 stability and protease binding in this therapeutic effect using a panel of PAI-1 mutants differing in half-life, protease binding, and Vn binding. PAI-1R binds Vn normally but does not inhibit proteases. PAI-1AK has ...
BACKGROUND Platelet-rich thrombi are resistant to lysis by tissue plasminogen activator (tPA). Plasminogen activator inhibitor-1 (PAI-1), a rapid inhibitor of tPA, may contribute to arterial thrombolysis resistance. However, few data are available regarding the effect of PAI-1 on arterial thrombolysis in animals. We used a murine carotid injury model to test the hypothesis that PAI-1 inhibits t...
Sepsis-induced acute kidney injury (AKI) contributes to the high mortality and morbidity in patients. Although the pathogenesis of AKI during sepsis is poorly understood, it is well accepted that plasminogen activator inhibitor-1 (PAI-1) and vitronectin (Vn) are involved in AKI. However, the functional cooperation between PAI-1 and Vn in septic AKI has not been completely elucidated. To address...
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