Diagnosis is the first analysis step for uncovering the root cause of failure for a defective integrated logic circuit. The conventional objective of identifying failure locations has been augmented with various physically-aware diagnosis techniques that are intended to improve both resolution and accuracy. Despite these advances, it is often the case, however, that resolution, i.e., the number...

Diagnosis is the first analysis step for uncovering the root cause of failure for a defective chip. It is a fast and non-destructive approach to preliminarily identify and locate possible defects in a failing chip. Despite many advances in diagnosis techniques, it is often the case, however, that resolution, i.e., the number of locations or candidates reported by diagnosis, exceeds the number o...

BACKGROUND It has been reported that cytomegalovirus (CMV) pp65-specific T cells can protect hematopoietic cell transplant (HCT) recipients from CMV complications. Two candidate CMV peptide vaccines composed of the HLA A*0201 pp65(495-503) cytotoxic CD8(+) T-cell epitope fused to 2 different universal T-helper epitopes (either the synthetic Pan DR epitope [PADRE] or a natural Tetanus sequence) ...

Cervical cancer is caused by high-risk, cancer-causing human papillomaviruses (HPV) and is the second highest cause of cancer deaths in women globally. The majority of cervical cancers express well-characterized HPV oncogenes, which are potential targets for immunotherapeutic vaccination. Here we develop a rabbit haemorrhagic disease virus (RHDV) virus-like particle (VLP)-based vaccine designed...

BACKGROUND The optic radiation (OR) is a white-matter bundle connecting the lateral geniculate body and the visual cortex. Phase difference-enhanced imaging (PADRE) is a new MRI technique that is able to achieve precise delineation of the OR. The aim of this study was to investigate the effect of age on the volume and signal intensity of the OR using PADRE, and to establish a volumetric referen...

This paper presents Padre, a new policy architecture for developing data replication systems. Padre simplifies design and implementation by embodying the right abstractions for replication in widely distributed systems. In particular, Padre cleanly separates the problem of building a replication system into the subproblems of specifying liveness policy and specifying safety policy, and it ident...

no. 424; Session G4.44 [email protected] EFFECT OF SMALL-HERD CLUSTERING ON THE GENETIC CONNECTEDNESS OF THE PORTUGUESE HOLSTEIN CATTLE POPULATION J.Vasconcelos and J.Carvalheira Centro Investigação em Biodiversidade e Recursos Genéticos (CIBIO), Universidade do Porto, Rua Padre Armando Quintas, 4485-661 Vairão, PORTUGAL, ICBAS-Universidade do Porto INTRODUCTION Accuracy of genetic evaluat...

a Marine Biological Association of the United Kingdom, The Laboratory, Citadel Hill, Plymouth PL1 2PB, UK b School of Biological Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK c CIBIO-UP, Centro de Investigação em Biodiversidade e Recursos Genéticos, Campus Agrário de Vairão, Rua Padre Armando Quintas, 4485-668 Vairão, Portugal d School of Biological Sciences, University o...

PURPOSE The medial medullary lamina (MML) separates the medial globus pallidus (GPm) from the lateral. The aim of this study was to assess the changes in appearance of MML related to age using the phase difference-enhanced (PADRE) imaging and to determine whether PADRE can depict the MML in the patients with Parkinson's disease (PD). MATERIALS AND METHODS We enrolled 20 patients with PD and 5...

Dendritic cells are special and powerful antigen-presenting cells that can induce primary immune responses against tumour-associated antigens. They can present antigens via both MHC-I and MHC-II, so they have the ability to stimulate both cytotoxic T lymphocytes and T helper cells. Furthermore, CD8+ cytotoxic T lymphocytes require activation by CD4+ T cells. This requires a CD4+ T cell activato...