We discuss a complicated case of a 34 year-old male with cutis verticis gyrata presenting simultaneously with hypertrophic osteoarthropathy and a pituitary macroadenoma. The patient was initially suspected of having acromegaly secondary to the pituitary adenoma but further workup showed normal insulin growth factor-1 and growth hormone levels inconsistent with acromegaly. Subsequent workup was ...

syndrome consisting of clubbing of the digits of the hands and feet, enlargement of the extremities secondary to periarticular and osseous proliferation, and painful and swollen joints. The condition has been divided into two categories, primary hypertrophic osteoarthropathy, also known as “pachydermoperiostosis”, and secondary hypertrophic osteoarthropathy, frequently referred to as “hypertrop...

A case of pachydermoperiostosis characterised by the presence of finger clubbing, periostosis, sweating of hands and feet is described. Modifications of capillaroscopic pattern and of arteriovenous anastomoses are reported. The periungual border and finger tip tissue showed diffuse endothelial hyperplasia, hyalinosis, and sclerosis with packing of collagen fibres. Electron microscopy showed hyp...