OBJECTIVE Benign prostatic hyperplasia (BPH) is the most common proliferative abnormality of the prostate affecting elderly men throughout the world. Epidemiologic studies have shown that diabetes significantly increases the risk of developing BPH, although whether anti-diabetic medications preventing the development of BPH remains to be defined. We have previously found that stromally expresse...

Baculovirus/insect cell expression systems have been in use for several years, often resulting in very high levels of expression of recombinant proteins (1). For expression of mature proteins the preferred vectors, such as pVL941 (2) or p36C (3), utilise the strong polyhedrin promoter and leader sequence. We recently reported the finding that the presence of a 24 bp bacterial sequence immediate...

Adhesins and adhesin-related accessory proteins of pathogenic mycoplasmas are required for cytadherence and the subsequent development of disease pathology. The classic example has been Mycoplasma pneumoniae, which causes primary atypical pneumonia in humans. Mutants of M. pneumoniae defective in adhesins (P1 and P30) or in adherence-accessory proteins (HMW1 through HMW4) are unable to colonize...

The origin recognition complex (ORC) plays a central role in eukaryotic DNA replication. Here we describe a unique ORC-like complex in Tetrahymena thermophila, TIF4, which bound in an ATP-dependent manner to sequences required for cell cycle-controlled replication and gene amplification (ribosomal DNA [rDNA] type I elements). TIF4's mode of DNA recognition was distinct from that of other charac...

We study the Shallit's conjecture which states that an in nite word ! is ultimately periodic if and only if lim n!1 inf jun(!)j n > 3 p5 2 ; where un(!) is the longest su x of length n pre x of ! which occurs also inside length n 1 pre x of !. We prove that a weaker condition holds, namely that the conjecture is true if the constant 3 p5 2 is replaced by 13 p69 10 . TUCS Research Group Mathemat...

presented at the Acellular Pertussis Vaccine Confer­ence, Bethesda, MD. Mooi, F. R., et al. (1998). Polymorphism in the Bordetella pertus­sis virulence factors P69/pertactin and pertussis toxin in theNetherlands: Temporal trends and evidence for vaccine-driven evolution. Infection and Immunity, 66, 670-675. Strebel, P., et al. (2001). Population-based incidence of pertussisamong...