The prognostic impact of human papillomavirus (HPV) in oropharyngeal cancer is generally acknowledged, and HPV-status assessed routinely clinical practice. Paradoxically, while the oral cavity seems predilection site for productive HPV-infections, figures on HPV-attribution squamous cell carcinoma (OCSCC) differ widely, uncertain. Major obstacles are lack reproducible assays to detect HPV nonor...

Objective In oropharyngeal squamous cell carcinoma (OP-SCC), the prevalence and distribution of clinical pathological lymph node metastasis in neck have been extensively reported. It served as basis for consensus recommendations on selection levels requiring a treatment. The objective study is to compare metastases HPV+ HPV− OP-SCC from large series patients with who underwent cervical lymph-no...

background: this research was accomplished to evaluate the ihc expression of p16 (ink4a) and ck17 in low grade cervical intraepithelial lesions (lsil), high grade cervical intraepithelial lesions (hsil) and invasive cervical carcinomas and to assess their correlation to hpv (16e6+18e6). methods: the study included (127) formalin-fixed paraffin-embedded cervical biopsies; of which 22 cases were ...

background: expression of epstein-barr virus latent member protein-1 (ebv lmp-1) and loss of p16 protein expression are documented in lymphoma, indicating a relationship between them, but this relationship is not clear and sometimes contradictory. thus, this study was conducted to examine the relationship between the loss of p16 and ebv lmp-1 expression in jordanian patients diagnosed with lymp...

Background: Cervical intraepithelial neoplasia (CIN) is a premalignant lesion capable of progressing to cervical cancer. Despite the existing well-defined criteria, the histomorphologic diagnosis is subject to high rates of discordance among pathologists. The aim of this study was to evaluate Ki-67 (MIB-1), CK17 and p16 INK4a (p16) markers by immunohistochemical methods in differentiating CIN f...

Background There are 2 known pathways for tumorigenesis of vulvar squamous cell carcinoma—a human papillomavirus–dependent pathway characterized by p16 overexpression and a papillomavirus–independent linked to lichen sclerosus, TP53 mutation. A correlation papillomavirus dependency with favorable prognosis has been proposed. Objective The objective the study was further understand role p53 stat...

OBJECTIVES This study aimed to examine (1) the expression of P16 protein relative to sites of presentation, immunophenotypic subgroups and proliferative indices of tumour cells, and (2) the relationship between p16 gene alterations and P16 protein overexpression in 70 cases of diffuse large B cell lymphoma (DLBCL). METHODS Expression of P16, CD10, BCL-6, MUM-1 and proliferation marker (Ki-67)...

Barrett’s esophagus (BE) is the only known precursor to esophageal adenocarcinoma, a cancer of which the incidence has been increasing at an alarming rate in Western countries. p16 lesions occur frequently in esophageal adenocarcinomas but their role in neoplastic progression is not well understood. We detected 9p21 loss of heterozygosity, p16 CpG island methylation, and p16 mutations in biopsi...