Let M and M ′ be two smooth hypersurfaces in C. A smooth mapping h : M → M ′ is a CR mapping if its components are annihilated by the induced CauchyRiemann operator on M . Let p0 ∈ M and suppose that near p0, h is the restriction of a holomorphic mapping H defined on one side of M near p0 and smooth up to M . We shall say that h satisfies the Hopf lemma property at p0 if the component of H norm...

The extracellular domain of the myelin P0 protein is believed to engage in adhesive interactions and thus hold the myelin membrane compact. We have previously shown that P0 can behave as a homophilic adhesion molecule through interactions of its extracellular domains (Filbin, M. T., F. S. Walsh, B. D. Trapp, J. A. Pizzey, and G. I. Tennekoon. 1990. Nature (Lond.) 344:871-872). To determine if t...

1. P. 74. Substitute the last seven lines by: There exists a unique gradient ̃ ∈ L2 (P0) with smallest L2 (P0)-norm such that ̇ = ̃ + (̇ − ̃) and (̇ − ̃) is orthogonal with respect to {g− h : g; h ∈ T (P0;P)}. Actually, ̃ is the orthogonal projection of ̇ on the L2 (P0)-closure of the latter space. 2. In Theorem 3(b), Corollary 3.3, and A(ii), p. 78 the following assumption is needed (which triv...

P0-Cre and Wnt1-Cre mouse lines have been widely used in combination with loxP-flanked mice to label and genetically modify neural crest (NC) cells and their derivatives. Wnt1-Cre has been regarded as the gold standard and there have been concerns about the specificity of P0-Cre because it is not clear about the timing and spatial distribution of the P0-Cre transgene in labeling NC cells at ear...

The central nervous system (CNS) of terrestrial vertebrates underwent a prominent molecular change when a tetraspan membrane protein, myelin proteolipid protein (PLP), replaced the type I integral membrane protein, P0, as the major protein of myelin. To investigate possible reasons for this molecular switch, we genetically engineered mice to express P0 instead of PLP in CNS myelin. In the absen...

We study the rate of convergence of Wilkinson’s shift iteration acting on Jacobi matrices with simple spectrum. We show that for AP-free spectra (i.e., simple spectra containing no arithmetic progression with 3 terms), convergence is cubic. In order 3, there exists a tridiagonal symmetric matrix P0 which is the limit of a sequence of a Wilkinson iteration, with the additional property that all ...

Seven monoclonal antibodies were raised against the immunoglobulin-like extracellular domain of P0 (P0-ED), the major protein of peripheral nervous system myelin. Mice were immunized with purified recombinant rat P0-ED. After fusion, 7 clones (P01-P07) recognizing either recombinant, rat, mouse, or human P0-ED were selected by ELISA and were characterized by Western blot, immunohistochemistry, ...

Mutations in P0 (MPZ), the major myelin protein of the peripheral nervous system, cause the inherited demyelinating neuropathy Charcot-Marie-Tooth disease type 1B. P0 is a member of the immunoglobulin superfamily and functions as a homophilic adhesion molecule. We now show that point mutations in the cytoplasmic domain that modify a PKC target motif (RSTK) or an adjacent serine residue abolish ...

We investigated changes in mRNA expression of the somatotropic, thyrotropic, and corticotropic axes of Langshan (LS) and Arbor Acres (AA) broiler chickens during embryonic and postnatal development. We found an inverse expression profile between pituitary growth hormone (GH) and hepatic GH receptor mRNA [postnatal d (P)28 to P42], insulin-like growth factor (IGF)-I, and IGF-IR (P0 to P42), resp...