The activity of cytochrome p450 isozyme 3A4 (CYP3A4) enzyme and P-glycoprotein (P-gp) is modulated by grapefruit juice and herbal drugs. CYP3A4 is the major phase I drug metabolizing enzyme and P-gp is an ATP-dependent drug efflux pump that regulates the intestinal absorption of orally administered drugs. Honey is commonly consumed as a dietary supplement. However, its influence on human CY...

One of the most important challenges in fight against cancer is acquired drug resistance. P-glycoprotein (P-gp), encoded by ABCB1 gene many organs, one factors involved development P-gp mainly efflux toxic substances such as xenobiotics from cell. In addition to these, it also plays a role drugs used treatment cancer, rate success reduces. Phenolic compounds are chemicals that naturally synthes...

BACKGROUND AND OBJECTIVE P-glycoprotein (P-gp) is a transmembrane efflux pump that actively extrude a variety of unrelated drugs from cancer cells, leading to the so-called multidrug resistance (MDR) phenomenon. However, P-gp has also been found in normal bone marrow and peripheral blood mononuclear cells (PBMC). Recently, the presence of P-glycoprotein in PBMC from human immunodeficiency virus...

We have identified platelet glycoprotein (GP) Ibalpha as a counterreceptor for P-selectin. GP Ibalpha is a component of the GP Ib-IX-V complex, which mediates platelet adhesion to subendothelium at sites of injury. Cells expressing P-selectin adhered to immobilized GP Ibalpha, and GP Ibalpha-expressing cells adhered to and rolled on P-selectin and on histamine-stimulated endothelium in a P-sele...

Background and objectives: In review of traditional Persian medicine (TPM) literature concerning multi drug therapy, a group of medicinal plants that are called "convoy drugs", agents which penetrate fast into whole or specific part of the body and accelerate delivery of drugs into specific target has been mentioned. In this study, the inhibitory effect of the aqueous extracts ...

Multidrug resistance (MDR) is one of the major obstacles to efficient chemotherapy against cancers, resulting from overexpression drug efflux transporters such as P-glycoprotein (P-gP). In present study, we aimed evaluate MDR reversal activity and synergistic therapeutic potential cationic anticancer peptide L-K6 with doxorubicin (DOX) on P-gP-overexpressing DOX-resistant MCF-7/ADR human breast...