Acetanilide like phenylbutazone is paraoxidized by the liver endoplasmic reticulum as a primary biotransformation step. Both compounds were given at different times to each of 10 healthy volunteer subjects and the plasma disappearances measured. Correlation was shown between plasma clearance values of the two compounds (r = + 0.7067; P < 0.05).Eight patients with hypoplastic anaemia after pheny...

Oxidative drug metabolism in liver microsomes from uremic rats. Uremia was achieved by subtotal nephrectomy in 50 to 70 day old male rats weighing 252.0± 20.1 g. Nephrectomized rats and sham-operated controls were sacrificed six days later. After liver microsomes had been isolated, microsomal cytochrome P-450 and cytochrome b5 content as well as microsomal specific activity for N-demethylation ...

One acetamide and 5 acetanilide herbicides are currently registered for use in the United States. Over the past several years, ethanesulfonic acid (ESA) and oxanilic acid (OA) degradation products of these acetanilide/acetamide herbicides have been found in U.S. ground waters and surface waters. Alachlor ESA and other acetanilide degradation products are listed on the U.S. Environmental Protect...

The current status of the Davydov/Scott model for energy transfer in proteins is reviewed. After a brief introduction to the theoretical framework and to the basic results, the problems of finite temperature dynamics and of the full quantum and mixed quantum-classical approximations are described, as well as recent results obtained within each of these approximations. A short survey of experime...

I. The Toxicity of Some Zirconium and Thorium Salts in Rats. L. T. McClinton and Jack Schubert 1 II. The Potentiating Effect of Antihistaminic Drugs Upon the Sedative Action of Barbiturates. Charles A. Winter . 7 III. Studies on Hydrocarbon-Epinephrine Induced Ventricular Fibrillation. Solomon Garb and Maynard B. Chenoweth 12 IV. The Inhibition of the Cholinesterase of Rat Brain by Methadon. Ge...

Pseudomonas aeruginosa AI 3 was able to grow in medium containing acetanilide (N-phenylacetamide) as a carbon source when NH4+ was the nitrogen source but not when urea was the nitrogen source. AIU mutants isolated from strain AI 3 grew on either medium. Urease levels in bacteria grown in the presence of urea were 10-fold lower when NH4+ or acetanilide was also in the medium, but there were no ...

The role of hepatic intrinsic clearance for metabolite formation from various precursors on subsequent metabolite elimination was was investigated in the once-through perfused rat liver preparation. Two pairs of acetaminophen precursors: [14C] phenacetin-d5 and [3H] phenacetin-do, [14C] acetanilide and [3H] phenacetin were delivered by constant flow (10 ml/min/liver) either by normal or retrogr...

The dynamics of acetanilide pesticide interactions with organic matter (OM) surrogates were examined using nuclear magnetic resonance (NMR) spectroscopy. Differences in the relative changes in (13)C and (1)H spin-lattice relaxation times (T(1)) were measured at multiple molecular sites of metolachlor and the probe compound acetanilide to identify interaction sites and/or surfaces between the mo...