نتایج جستجو برای: p 014

تعداد نتایج: 1270684  

Journal: :BMC Clinical Pharmacology 2009
Roslyn Varki Ed Pequignot Mark C Leavitt Andres Ferber Walter K Kraft

BACKGROUND AVI-014 is an egg white-derived, recombinant, human granulocyte colony-stimulating factor (G-CSF). This healthy volunteer study is the first human investigation of AVI-014. METHODS 24 male and female subjects received a single subcutaneous injection of AVI-014 at 4 or 8 mcg/kg. 16 control subjects received 4 or 8 mcg/kg of filgrastim (Neupogen, Amgen) in a partially blinded, parall...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2016
Daniel D Von Hoff Monica M Mita Ramesh K Ramanathan Glen J Weiss Alain C Mita Patricia M LoRusso Howard A Burris Lowell L Hart Susan C Low Donald M Parsons Stephen E Zale Jason M Summa Hagop Youssoufian Jasgit C Sachdev

PURPOSE First-in-human phase I trial to determine the safety, pharmacokinetics, and antitumor activity of BIND-014, a novel, tumor prostate-specific membrane antigen (PSMA)-targeted nanoparticle, containing docetaxel. EXPERIMENTAL DESIGN Patients with advanced solid tumors received BIND-014 every three weeks (n = 28) or weekly (n = 27), with dose levels ranging from 3.5 to 75 mg/m(2) and 15 t...

2016
Xiao-qin Jia Shu Zhang Hui-jun Zhu Wei Wang Jin-hong Zhu Xu-dong Wang Jian-feng Qiang

Phosphoglycerate dehydrogenase (PHGDH) plays an essential role in cancer-specific metabolic reprogramming. It has been reported as a putative metabolic oncogene in several types of human malignant tumors, such as breast cancer and melanoma. To date, PHGDH expression in colorectal cancer (CRC) as well as its association with clinicopathological characteristics and prognostic implication remain u...

Journal: :Archivos de la Sociedad Espanola de Oftalmologia 2011
R Martínez A Acera J Soria N González T Suárez

PURPOSE To evaluate the concentration of allergic mediators in tears of children with seasonal allergic conjunctivitis (SAC) and perennial allergic conjunctivitis (PAC) compared with controls. METHODS Twenty children with allergic conjunctivitis (17 SAC, and 3 PAC) and sixteen healthy children were included in this study. Tear samples were collected using a Merocel sponge (Oasis, 0525), and i...

2015
Andrew Dalziell James Boyle Nanette Mutrie

Recent research has confirmed a positive relationship between levels of physical activity and academic achievement. Some of these studies have been informed by neurological models of Executive Functioning (EF). There is a general consensus within the literature that the three core EF skills are; working memory, inhibitory control and cognitive flexibility. The development of these core EF skill...

2011

The mating strategies of male and female Ectropis oblique Prout were investigated with the aid of male antennae as an electroantennogram (EAG) detector and capillary-GC analysis. Each male was capable of mating with several females, but females that had received a spermatophore mated only once. Antennae dissected from males 0, 1, 2, 3, and 4 d post-mating and antennae from virgin males of corre...

Journal: :The journal of the American Academy of Psychiatry and the Law 2015
R Scott Johnson David P Graham Kristi Sikes Andrea Nelsen Andrea Stolar

This descriptive analysis is an examination of the extent to which a veteran's mental health diagnosis or the initial criminal charge committed before program enrollment relate to a greater propensity for sanctions, harsher sanctions, higher rates of relapse on substances, or overall program compliance. This is a retrospective descriptive analysis that focuses on those participants in the Harri...

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