Four 28-d trials were conducted using a total of 432 pigs, with average initial weight across trials ranging from 6.3 to 9.7 kg, to estimate the tryptophan (trials 1 and 2) and threonine (trials 3 and 4) requirements of pigs fed low protein, corn-sunflower meal diets. The effect of tryptophan, threonine and protein level on serum calcium, phosphorus and zinc also was studied. The diets containe...

Background Virtual-Morris Water Maze (V-MWM) has been developed to assess potential hippocampal-dependent memory decline. Previous attempts showed the V-MWM was sensitive in detecting age-related reference decline, but our pilot study indicated that elderly often could not complete tasks within 60s. Therefore, we have investigated further use of a spatial working paradigm evaluate one-trial lea...

PURPOSE There are no accurate prognostic biomarkers specific for rectal cancer. Epigenetic aberrations, in the form of DNA methylation, accumulate early during rectal tumor formation. In a preliminary study, we investigated absolute quantitative methylation changes associated with tumor progression of rectal tissue at multiple genomic methylated-in-tumor (MINT) loci sequences. We then explored ...

Health professionals in Tanzania report a perceived need for sexual and reproductive health communication training to meet patient needs reduce disparities. Simulation optimizes clinical performance public entrustment. The study describes the development, feasibility, acceptability measures of evidence-based, Afrocentric, standardized scenarios train nursing, medical, midwifery students Tanzani...

BACKGROUND Surgical resection is regarded as the only curative option for resectable oesophageal cancer, but pulmonary complications occurring in more than half of patients after open oesophagectomy are a great concern. We assessed whether minimally invasive oesophagectomy reduces morbidity compared with open oesophagectomy. METHODS We did a multicentre, open-label, randomised controlled tria...

Ruxolitinib is JAK1/JAK2 inhibitor with established clinical benefit in myelofibrosis (MF). We analyzed long-term outcomes of 107 patients with intermediate-2 or high-risk MF receiving ruxolitinib at MD Anderson Cancer Center (MDACC) on phase 1/2 trial. After a median of 32 months of follow-up, 58 patients (54%) were still receiving ruxolitinib, with overall survival (OS) of 69%. The splenomega...

Ruxolitinib is JAK1/JAK2 inhibitor with established clinical benefit in myelofibrosis (MF). We analyzed long-term outcomes of 107 patients with intermediate-2 or high-risk MF receiving ruxolitinib at MD Anderson Cancer Center (MDACC) on phase 1/2 trial. After a median of 32 months of follow-up, 58 patients (54%) were still receiving ruxolitinib, with overall survival (OS) of 69%. The splenomega...

In this paper we test the effects of social interactions in embodied problem solving by employing a Scrabble-like setting. 28 pairs of participants had to generate as many words as possible from 2 balanced sets of 7 letters, which they could manipulate, either individually or collectively. Collaborating makes pairs significantly more productive (M=68.7 SD=16.7) than the best of the two individu...

Objectives. To investigate whether lifestyle-only intervention in obese children who maintain or lose a modest amount of weight redistributes parameters of body composition and reverses metabolic abnormalities. Study Design. Clinical, anthropometric, and metabolic parameters were assessed in 111 overweight or obese children (CA of 11.3 ± 2.8 years; 63 females and 48 males), during 8 months of l...