BACKGROUND Opioid guidelines recommend opioid rotation and switching for patients who do not achieve adequate pain relief or who experience intolerable adverse events (AEs) with their current opioid. However, specific recommendations and protocols for opioid rotation are lacking, making the practice time consuming and difficult for primary care physicians to accomplish independently or coordina...

The sedative and toxic properties of morphine, and five semi-synthetic opiates (diamorphine, dihydromorphinone, dihydrocodeine, oxymorphone and oxycodone) have been determined by giving them, in a double-blind trial, as pre-anaesthetic medication to a standard female population. Diamorphine and dihydromorphinone produced the best sedation whilst dihydrocodeine was least efficient in this respec...

Methods. In order to determine the potential impact on cognitive performance of the increased absorption of oxymorphone ER, fed versus fasting, we conducted a randomized, rater-blinded, crossover study in 30 opioid-tolerant subjects, using tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB). The subjects randomly received 40 mg oxymorphone ER after a high-fat meal of app...

Abstract A simple and sensitive chemiluminescence (CL) method was developed for direct quantification of oxymorphone, a µ opioid agonist that is approximately 10 times more potent than morphine. In this method potassium permanganate in polyphosphoric acid was used as CL reagent. Using this method, oxymorphone can be determined over the concentration ranges 13.5-337.8 ng mL-1 and 0.34-6.76...

BACKGROUND A formulation of crush-resistant extended-release opioids may deter abuse. The purpose of this study was to evaluate the bioequivalence of oxymorphone extended-release (Oxy-ER) and a crush-resistant formulation of oxymorphone extended-release (Oxy-CRF). METHODS In three open-label, randomized studies, healthy adults at a clinical research center received two single oral doses of Ox...

abstract a simple and sensitive chemiluminescence (cl) method was developed for direct quantification of oxymorphone, a µ opioid agonist that is approximately 10 times more potent than morphine. in this method potassium permanganate in polyphosphoric acid was used as cl reagent. using this method, oxymorphone can be determined over the concentration ranges 13.5-337.8 ng ml-1 and 0.34-6.76 µg ml...