zno nps (zinc oxide nanoparticles) has generated significant scientific interest as a novel antibacterial and anticancer agent. since oxidative stress is a critical determinant of zno nps-induced damage, it is necessary to characterize their underlying mode of action. different structural and physicochemical properties of zno nps such as particle surface, size, shape, crystal structure, chemica...

background: oxidative stress is described as the formation of toxic effect due to the deficiency of cellular antioxidative level toward the level of reactive oxygen species (ros). the excess production of ros or the decrease in the antioxidative defense system could be the cause for oxidative stress. 7,12-dimethylbenz[a]anthracene (dmba) that is known to be the major cause the increment in lipi...

Free radical can be defined as a molecule or molecular fragments containing unpaired electron in the outer orbital, which react with nearby molecules to get stability. There are two types of them in the body: oxygen free radicals and nitrogen free radicals. Our body has an antioxidant defense system which prevents accumulation of these radicals. There is a balance between free radical produc...

this study aimed to investigate the effect of different levels of silymarin against lead induced oxidative stress in broiler chickens. therefore, 240 broiler chickens of ross 308 allocated to 24 experimental units in a completely randomized design with factorial 2x3 arrangements and four replicates of 10 birds. the experimental diets containing silymarin at 3 levels (0, 100, 200 mg/kg) and 2 le...

methylsulfonylmethane (msm) is a sulfur-containing compound commonly found in diet and known to reduce oxidative stress. this trial was conducted to determine whether single dose supplementation with msm attenuates post-exercise oxidative stress in healthy untrained young men. sixteen untrained men volunteered for this study. participants were randomized in a double-blind placebo-controlled fas...

standardization of induction of oxidative stress with fenton mixture (fm) in isolated perfused rat kidney and the antioxidant effect of terminalia arjuna bark in the isolated oxidatively stressed rat kidney has been evaluated. six groups each containing eight isolated perfused rat kidneys were used for the present study and the oxidative stress was induced by perfusing the isolated kidneys with...

statins have antioxidant and anti-inflammatory effects that are not directly related to their cholesterol-lowering activity. this study aimed to investigate the effect of simvastatin on the extent of tissue damage in cisplatin-induced nephrotoxicity. simvastatin was orally given to rats in different doses (1, 2 and 4 mg/kg), 1 h prior to cisplatin injection (5 mg/kg, i.p.). all animals were dec...

background: prepubertal varicocele has the most devastating effects on the testes. oxidative stress is the major cause leading to infertility in varicocele. the antioxidant properties of flaxseed (fs) treatment in some oxidative diseases have been reported. objective: this study aimed to evaluate the antioxidant effect of fs in prepubertal rats with experimental varicocele. materials and method...

introduction: acrylamide (acr) known as a neurotoxic agent in human and animals. previous studies have been shown; fasudil improves neurological deficit and neuronal damage. in this study, the effect of fasudil, potent rho-kinase inhibitor, on acr-induced cytotoxicity was evaluated using pc12 cells as a suitable in vitro model. materials and methods: pc12 cells were exposed to different concent...