The acute and chronic action of the oxidant gases ozone, nitrogen dioxide and oxygen on the morphological appearance of cells of the alveolar and bronchiolar epithelium is reviewed. Type I cells of the alveolar and ciliated cells of the bronchiolar epithelium appear to be sensitive targets for the oxidant gases. The degree of damage is influenced by age, nutritional status and the development o...

INTRODUCTION Oxidative stress affects clinical outcome in critically ill patients. Although high-density lipoprotein (HDL) particles generally possess anti-oxidant capacities, deleterious properties of HDL have been described in acutely ill patients. The impact of anti-oxidant HDL capacities on clinical outcome in critically ill patients is unknown. We therefore analyzed the predictive value of...

objective(s): methylsulfonylmethane (msm) is a sulfur-containing compound found in a wide range of human foods including fruits, vegetables, grains and beverages. in this study the effect of msm pretreatment on acetaminophen induced liver damage was investigated. materials and methods: male sprague dawley rats were pretreated with 100 mg/kg msm for one week. on day seven rats were received acet...

This article discusses some of the mechanisms through which alcohol, delivered pre- or postnatally, alters the activity of the rodent hypothalamic-pituitary-adrenal (HPA) axis. We show that blockade of prostaglandin synthesis, but not opiate receptors, modestly interfered with the HPA axis to acute alcohol injection. Pretreatment with a low dose of alcohol (0.3 g/kg) did not significantly modif...

objective(s): biological applications of gold nanoparticles have limitations because of the toxic chemicals used in their synthesis. curcumin can be used as reducing as well as capping agent in synthesis of gnps to eliminate the cytotoxicity. conjugation of curcumin to gold also helps in increasing its solubility and bioavailability. materials and methods: here we report synthesis of gold nanop...

introduction: shallot is a plant which belongs to alium and albale family , this is a native plant from iran which is self – grown in high zones. by regard to further use of medicine and plant’s product , use of herbal plants has on important nole in medical treatment and preventi of diseale. the purpose of this study is the photo chemistry properties and anti – bacterial effects of this plant....

background: the aim of this study was to assess effects of cysteamine as an anti-oxidant on rate of in vitro maturation of oocyte and determination of its effects on spindle size and shape. methods: pre-mature mice were primed with pregnant mare stimulating gonadotrophin (pmsg) and germinal vesicle (gv) stage oocytes were obtained 48 h after. the oocytes were cultured in tissue culture medium (...

background: artemisia species with common persian name of dermaneh are found all over iran and are used for treatment in infectious diseases such as malaria, hepatitis and other diseases. some artemisia species are used in traditionally as tonic and anti-helmintic in north of iran. objective: the aim of this study was to investigate chemical composition of the essential oil of artemisia hausskn...

PURPOSE Oxidative damage plays an important role in atherosclerosis development. Statin drugs have anti-oxidant properties, but the clinical value of their antioxidant properties remains unclear. In this study, our aims were: (1) to assess the anti-oxidant effects of statins in patients with coronary artery disease (CAD) using a newly developed valid measure of total oxidant and anti-oxidant ca...

Curcumin metabolites namely curcumin monoglucuronide and curcumin diglucuronide were synthesized using an alternative synthetic approach. The anti-oxidant potential of these curcumin glucuronides was compared with that of curcumin using DPPH scavenging method and Oxygen Radical Absorbance Capacity (ORAC) assay. The results show that curcumin monoglucuronide exhibits 10 fold less anti-oxidant ac...