Pregnane X receptor (PXR, NR1I2) is activated by various chemically unrelated compounds, including environmental pollutants and drugs. We proceeded here to in vitro screening of 28 pesticides with a new reporter system that detects human pregnane X receptor (hPXR) activators. The cell line was obtained by a two-step stable transfection of cervical cancer HeLa cells. The first transfected cell l...

In this work, an environmentally friendly sample pre-treatment method, Ultrasound Assisted Surfactant Enhanced Emulsification Microextraction (UASEME) followed with spectrofluorimetry was performed for determination of oxadiazon residues in water samples. After the determination of the most suitable extraction solvent and its volume, other parameters such as type and concentration of surfactant...

A field demonstration and pot experiments were implemented to assess the effect of paraquat, oxadiazon, oxyfluorfen herbicides in controlling selected populations fleabane Conyza bonariensis (L.), grown central valley Jordan. mature seeds collected from six investigated sites (five Jordan named P1, P2, P3, P4, P5, one University Campus P6). Only proved be C. via ITS assessment involved glasshou...

Peroxidizing herbicides were assayed for their capacity to accumulate tetrapyrrole-like compounds in the liquid culture medium when growing the xanthophycean alga Bumilleriopsis filiformis. W e have isolated and purified this compound by H P L C . For identification optical, fluorescence, N M R and mass spectroscopy were employed. All these techniques showed that the accumulation product is pro...

1 These authors contributed equally to the study. ABSTRACT Pregnane X receptor (hPXR, NR1I2) is activated by various chemically unrelated compounds, including environmental pollutants and drugs. We proceeded here to in vitro screening of 28 pesticides with a new reporter system that detects hPXR activators. The cell line was obtained by a two-step stable transfection of cervical cancer HeLa cel...

in this work, an environmentally friendly sample pre-treatment method, ultrasound assisted surfactant enhanced emulsification microextraction (uaseme) followed with spectrofluorimetry was performed for determination of oxadiazon residues in water samples. after the determination of the most suitable extraction solvent and its volume, other parameters such as type and concentration of surfactant...

Several laboratories have demonstrated recently that photobleaching herbicides such as acifluorfen and oxadiazon cause accumulation of protoporphyrin IX (PPIX), a photodynamic pigment capable of herbicidal activity. We investigated, in acifluorfen-treated tissues, the in vivo stability of PPIX, the kinetics of accumulation, and the correlation between concentration of PPIX and herbicidal damage...