It is believed that 3.2 billion bp of the human genome harbor approximately 35000 protein-coding genes. On average, one could expect one gene per 300000 nucleotides (nt). Although the distribution of the genes in the human genome is not random,it is rather surprising that a large number of genes overlap in the mammalian genomes. Thousands of overlapping genes were recently identified in the hum...

background nasal valve collapse and especially internal nasal valve insufficiency is a common cause of nasal airway obstruction. this study compares the effects of spreader graft and overlapping lateral crural technique on rhinoplasty by rhinomanometry. methods fifty patients were randomly assigned into two groups and underwent spreader graft or overlapping lateral crural technique. objective a...

The products of in-frame overlapping genes II and X carried by the filamentous phage f1 genome are proteins with required but opposing functions in phage DNA replication. Their normal relative levels are important for continuous production of phage DNA without killing infected Escherichia coli hosts. Here we identify several factors responsible for determining the relative levels of pII and pX ...

BACKGROUND Nasal valve collapse and especially internal nasal valve insufficiency is a common cause of nasal airway obstruction. This study compares the effects of spreader graft and overlapping lateral crural technique on rhinoplasty by rhinomanometry. METHODS Fifty patients were randomly assigned into two groups and underwent spreader graft or overlapping lateral crural technique. Objectiv...

Recent publications have raised concerns about the reliability of microarray technology because of the lack of reproducibility of differentially expressed genes (DEGs) from highly similar studies across laboratories and platforms. The rat toxicogenomics study of the MicroArray Quality Control (MAQC) project empirically revealed that the DEGs selected using a fold change (FC)-based criterion wer...

Niche dependent differential gene loss and overlapping genes have been proposed as means of achieving genome reduction by retaining indispensable genes and compressing maximum amount of information in available sequence space. Herein, we analyzed the differential gene loss and overlapping genes in bacterial genomes with different lifestyles. Our results clearly suggest that gene loss and overla...