The aim of the present study was to understand the interrelationships between stress, hormones and basic ovarian functions in the ovary. For this purpose, we compared the expression of markers of proliferation (PCNA, cyclin B1), of apoptosis (Bax, caspase-3) and secretory activity (release of progesterone, P(4), and insulin-like growth factor, IGF-I) in whole ovarian follicles and granulosa cel...

The aim of the present study is to understand the hormonal mechanisms of the effect of malnutrition on ovarian follicle functions. For this purpose, we examined the effect of malnutrition/serum deprivation, addition of metabolic hormones and gonadotropin (IGF-I, leptin and FSH) and their combination on the release of progesterone (P4), testosterone (T), estradiol (E2) and insulin-like growth fa...

background: nandrolone decanoate (nd) is an anabolic androgenic steroid (aas) which influences the ovarian structure and function. we assessed the effects of nd on the ovarian volume, number of primordial follicles, and level of hormones and also evaluated the modulatory effects of gonadotropins on the histopathological changes imposed by the administration of nd. methods: six groups of sprague...

background: premature ovarian failure (pof) is a common condition; its incidence is estimated to be as great as 1 in 100 by the age of 40 years. physiologic replacement of ovarian steroid hormones seems rational until the age of normal menopause. temporary return of ovarian function and pregnancy may occur rarely in women with pof. we report a case of pof who conceived during hormone replacemen...

Introduction: Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in females of reproductive age group. It characterised by menstrual irregularities, enlarged ovaries, infertility, high levels male hormones, excess hair on face and body, acne obesity. PCOS can result from abnormal function hypothalamic-pituitary-ovarian axis. Women with have an increased risk diabetes, bloo...

Background: Nandrolone decanoate (ND) is an anabolic androgenic steroid (AAS) which influences the ovarian structure and function. We assessed the effects of ND on the ovarian volume, number of primordial follicles, and level of hormones and also evaluated the modulatory effects of gonadotropins on the histopathological changes imposed by the administration of ND. Methods: Six groups of Sprague...

The formation of granulosa-cell tumors and subcutaneous tissues or testes of intact and cas luteomas in intrasplenic ovarian grafts in castrated trated mice did not readily become tumorous. rats (1) and in intrasplenic and intrapancreatic The present experiments are concerned with the ovarian grafts in castrated male and female mice influence of gonadal and gonadotrophic hormones has been repor...

Bone marrow-derived stem cells (BMDSCs) play an essential role in organ repair and regeneration. The molecular mechanisms by which hormones control BMDSCs proliferation and differentiation are unclear. Our aim in this study was to investigate how a lack of ovarian or/and thyroid hormones affects stem cell number in bone marrow lineage. To examine the effect of thyroid or/and ovarian hormones on...

The current studies demonstrate the critical importance of ovarian hormones in the initiation and promotion of carcinogenesis of mammary glands in rats by polynuclear hydrocarbons. Removal of ovarian hormones from the rats immediately after the ad ministration of the carcinogenic hydrocarbons either inhibited or profoundly reduced the incidence of mammary cancer. Excision of ovaries beyond 7 da...