Only 23% of patients with otosclerosis observed by histological changes also present clinical manifestations [2], because in most cases otosclerosis reaches small regions of the optic capsule without causing clinical symptoms (histological form) [3]. It is estimated that between 9 and 10% Of patients with otosclerosis will develop deep sensorineural hearing loss due to the evolution of the dise...

Abstract Purpose of Review This review will highlight recent outcome-based evidence guiding decision making for cochlear implantation in advanced otosclerosis, related complications, and technical surgical considerations otosclerosis the obstructed cochlea. Recent Findings Cochlear results consistent, excellent auditory outcomes with improvement both objective speech recognition scores subjecti...

Unilateral otosclerosis combined with avascular necrosis of stapes crura is a rare entity. it should be considered in a case of high grade otosclerosis. Symptoms are the same as in patients who suffer from common otosclerosis. Patients complain on progressive hearing loss and tinnitus. The diagnosis is made clinically by conventional audiologic evaluation and radiologically by x-ray mastoid Sch...

OBJECTIVE To evaluate whether otosclerosis is an underlying mechanism for the production of cupular deposits and to study the association between cupular deposits and dysequilibrium in otosclerosis. DESIGN Retrospective human temporal bone (TB) study. The incidence of cupular deposits in these 70 TBs was analyzed. Correlations between cupular deposits and vestibular symptoms, endosteal involv...

Genetic predisposition of otosclerosis has long been suspected, but unclarified. Unique coexpression pattern of measles virus receptor (CD46) splicing isoforms in the human otic capsule is assumed, since otosclerosis is a measles virus-associated organ-specific disease. In order to identify CD46 involved in the pathogenesis of otosclerosis, we used representative groups of histologically diagno...

BACKGROUND AND OBJECTIVE: Otosclerosis is the most common disorder of the bony labyrinth and stapes only affecting humans. Otosclerosis is considered a major cause of acquired hearing loss. This study aimed to evaluate the audiological characteristics of patients with otosclerosis referring to the Ear, Nose, and Throat (ENT) clinics of

OBJECTIVES/HYPOTHESIS To propose an evidence-based strategy for the management of patients with advanced otosclerosis accompanied by severe to profound hearing loss. STUDY DESIGN Systematic review of the literature and development of treatment guidelines. METHODS A systematic review was conducted on (advanced) otosclerosis and cochlear implantation or stapedotomy. We focused on hearing resu...

Otosclerosis, the single most common cause of hearing impairment in white adults, is characterised by bone dystrophy localized to the otic capsule and isolated endochondral bone sclerosis with alternating phases of bone resorption and formation. Conductive hearing loss develops when otosclerotic foci invade the stapedio-vestibular joint (oval window) and interfere with free motion of the stapes...

INTRODUCTION Otosclerosis (OS) is the primary disease of the human temporal bone characterized by conductive hearing loss and tinnitus. The exact pathogenesis of tinnitus in otosclerosis patients is not known and factors affecting the tinnitus outcome in otosclerosis patients are still controversial. OBJECTIVES To find the effect of stapedotomy on tinnitus for otosclerosis patients. METHODS...

Otosclerosis is a disease of the human otic capsule (1). Otosclerosis is well known to the otologist, as it is the most common cause for progressive conductive hearing loss in early adulthood. As hearing loss progresses, a sensorineural component is sometimes seen, resulting in a mixed hearing loss. In 1% of cases, the disease is considered purely cochlear, presenting with a sensorineural heari...