BACKGROUND Prognosis of traumatic osteonecrosis of femoral head in children is poor for either conservative treatment or surgical intervention. Intravenous bisphosphonate is an expecting medication to reduce femoral head resorption and to prevent femoral head collapse after traumatic osteonecrosis. This mechanism will reduce development of osteoarthritis and disability in the future. OBJECTIV...

Background: Femoral head osteonecrosis is a progressive disease with disabling outcomes in hip joint if not treated.This study was designed to compare the effects of zoledronic acid plus vitamin E versus zoledronic acid alone insurgical induced femoral head osteonecrosis in rabbits.Methods: 26 Japanese white adult normal male rabbits at 28-32 weeks old were undertaken surgical femoraldislocatio...

BACKGROUND A major cause of osteonecrosis of the femoral head is interruption of a blood supply to the proximal femur. In order to evaluate blood circulation and pathogenetic alterations, a pig femoral head osteonecrosis model was examined to address whether ligature of the femoral neck (vasculature deprivation) induces a reduction of blood circulation in the femoral head, and whether transphys...

Background: Femoral head avascular necrosis is the cause of paralyzing status of youth population. Initial diagnosisis the main element in treating the disease. Bone grafting and core decompression are the approved cures at the earlysteps of the disease. Hip replacement in a total manner is the common cure in the final stages. The optimal treatment inthe intermediate stages is...

Platelet-rich plasma (PRP) is autologous and multifunctional. Platelet concentrate from blood contains highly concentrated platelets and various types of cells, including growth factors. PRP promotes the recovery of cell proliferation and differentiation. Osteonecrosis of the femoral head is a disease caused by femoral head damage or an insufficient blood supply, which leads to the death of bon...

Total hip replacement in patients with advanced osteonecrosis of the femoral head is often complicated by early loosening of the femoral component. Recent evidence has suggested that abnormal bone extending into the proximal femur may be responsible for the early failure of the femoral component. We aimed to identify which patients were at high risk of early failure by evaluating gadolinium-enh...

OBJECTIVE The purpose of this article is to relate intramedullary perfusion of the proximal femur to severity of osteonecrosis of the femoral head by using dynamic contrast-enhanced MRI (DCE-MRI). SUBJECTS AND METHODS Twelve patients (14 symptomatic hips) who underwent DCE-MRI and had subsequent core decompression of the femoral head were examined. Hips were graded for severity according to M...

In about 50% of cases, osteonecrosis of the femoral head is known to occupy more than one site. There is controversy as to whether a single focus may increase in size. We have reviewed 606 consecutive femoral heads which had been surgically removed for osteonecrosis. Extension of osteonecrosis was observed in only two (0.3%) and was confirmed histopathologically by the enlargement of the necrot...

BACKGROUND Osteonecrosis of the femoral head is a debilitating disease that involves impaired blood supply to the femoral head and leads to femoral head collapse. METHODS We use whole-exome sequencing and Sanger sequencing to analyse a family with inherited osteonecrosis of the femoral head and fluorescent Ca(2+) imaging to functionally characterise the variant protein. RESULTS We report a ...

Osteonecrosis of the femoral head is an uncommon complication following hip arthroscopy, generally due to an excessive traction of the limb and high intracapsular pressures of the hip. This complication entails catastrophic outcomes for the femoral head with collapse and degeneration, resulting in another surgical procedure. We present a case of a 21 year-old soccer player that underwent arthro...